• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

大鼠下丘脑室旁核中促肾上腺皮质激素释放因子、糖皮质激素受体和苯乙醇胺-N-甲基转移酶免疫反应性结构分布的形态计量学分析

Morphometrical analysis of the distribution of corticotrophin releasing factor, glucocorticoid receptor and phenylethanolamine-N-methyltransferase immunoreactive structures in the paraventricular hypothalamic nucleus of the rat.

作者信息

Agnati L F, Fuxe K, Yu Z Y, Härfstrand A, Okret S, Wikström A C, Goldstein M, Zoli M, Vale W, Gustafsson J A

出版信息

Neurosci Lett. 1985 Mar 15;54(2-3):147-52. doi: 10.1016/s0304-3940(85)80070-7.

DOI:10.1016/s0304-3940(85)80070-7
PMID:3873028
Abstract

By means of the indirect immunoperoxidase technique the corticotrophin releasing factor (CRF) and glucocorticoid receptor (GR) immunoreactive nerve cell bodies and the phenylethanolamine-N-methyltransferase (PNMT) immunoreactive nerve terminals in the paraventricular hypothalamic nucleus of the rat have been mapped out in adjacent vibratome sections (30 micron thick). By means of morphometrical analysis using a semiautomatic image analyser, it was possible to obtain density maps of CRF, GR and PNMT immunoreactive structures within the paraventricular hypothalamic nucleus. The statistical analysis by the use of correlation coefficients gives evidence that the PNMT immunoreactive nerve terminals innervate the majority of the CRF immunoreactive nerve cell bodies and that GR are located in the majority of the CRF immunoreactive neurons.

摘要

通过间接免疫过氧化物酶技术，在大鼠下丘脑室旁核相邻的振动切片（30微米厚）中，绘制出了促肾上腺皮质激素释放因子（CRF）和糖皮质激素受体（GR）免疫反应性神经细胞体以及苯乙醇胺 -N-甲基转移酶（PNMT）免疫反应性神经终末的分布图。通过使用半自动图像分析仪进行形态计量分析，得以获取下丘脑室旁核内CRF、GR和PNMT免疫反应性结构的密度图。使用相关系数进行的统计分析表明，PNMT免疫反应性神经终末支配着大多数CRF免疫反应性神经细胞体，并且GR位于大多数CRF免疫反应性神经元中。

相似文献

1
Morphometrical analysis of the distribution of corticotrophin releasing factor, glucocorticoid receptor and phenylethanolamine-N-methyltransferase immunoreactive structures in the paraventricular hypothalamic nucleus of the rat.大鼠下丘脑室旁核中促肾上腺皮质激素释放因子、糖皮质激素受体和苯乙醇胺-N-甲基转移酶免疫反应性结构分布的形态计量学分析
Neurosci Lett. 1985 Mar 15;54(2-3):147-52. doi: 10.1016/s0304-3940(85)80070-7.
2
Morphometrical and microdensitometrical studies on phenylethanolamine-N-methyltransferase- and neuropeptide Y-immunoreactive nerve terminals and on glucocorticoid receptor-immunoreactive nerve cell nuclei in the paraventricular hypothalamic nucleus in adult and old male rats.成年和老年雄性大鼠下丘脑室旁核中苯乙醇胺 - N - 甲基转移酶和神经肽Y免疫反应性神经末梢以及糖皮质激素受体免疫反应性神经细胞核的形态计量学和显微密度测定研究
Neuroscience. 1988 Aug;26(2):479-92. doi: 10.1016/0306-4522(88)90163-7.
3
Adrenergic innervation of corticotropin releasing factor (CRF)-synthesizing neurons in the hypothalamic paraventricular nucleus of the rat. A combined light and electron microscopic immunocytochemical study.
Histochemistry. 1986;84(3):201-5. doi: 10.1007/BF00495783.
4
Coexistence of c-Fos and glucocorticoid receptor immunoreactivities in the CRF immunoreactive neurons of the paraventricular hypothalamic nucleus of the rat after acute immobilization stress.急性制动应激后大鼠下丘脑室旁核促肾上腺皮质激素释放因子免疫反应性神经元中c-Fos与糖皮质激素受体免疫反应性的共存
Neurosci Lett. 1993 Jan 12;149(2):149-52. doi: 10.1016/0304-3940(93)90758-d.
5
Glucocorticoid receptor-immunoreactivity in corticotrophin-releasing factor afferents to the locus coeruleus.促肾上腺皮质激素释放因子传入蓝斑纤维中的糖皮质激素受体免疫反应性
Brain Res. 1999 Jan 16;816(1):17-28. doi: 10.1016/s0006-8993(98)00900-7.
6
Ultrastructural localization of glucocorticoid receptor (GR) in hypothalamic paraventricular neurons synthesizing corticotropin releasing factor (CRF).在下丘脑合成促肾上腺皮质激素释放因子（CRF）的室旁核神经元中糖皮质激素受体（GR）的超微结构定位。
Histochemistry. 1987;87(5):407-12. doi: 10.1007/BF00496811.
7
Presence of glucocorticoid receptor immunoreactivity in corticotrophin releasing factor and in growth hormone releasing factor immunoreactive neurons of the rat di- and telencephalon.大鼠间脑和端脑中促肾上腺皮质激素释放因子及生长激素释放因子免疫反应性神经元中糖皮质激素受体免疫反应性的存在。
Neurosci Lett. 1987 Jun 1;77(1):25-30. doi: 10.1016/0304-3940(87)90601-x.
8
Differential organization of synapses immunoreactive to phenylethanolamine-N-methyltransferase or neuropeptide Y in the parvicellular compartments of the hypothalamic paraventricular nucleus of the rat.大鼠下丘脑室旁核小细胞区中对苯乙醇胺 -N-甲基转移酶或神经肽Y免疫反应的突触的差异组织
J Chem Neuroanat. 1993 Mar-Apr;6(2):55-67. doi: 10.1016/0891-0618(93)90028-3.
9
Increase of corticotropin-releasing factor staining in rat paraventricular nucleus neurones by depletion of hypothalamic adrenaline.通过下丘脑肾上腺素耗竭增加大鼠室旁核神经元中促肾上腺皮质激素释放因子染色
Nature. 1984;310(5973):140-1. doi: 10.1038/310140a0.
10
Synaptic interaction of serotonergic axons and corticotropin releasing factor (CRF) synthesizing neurons in the hypothalamic paraventricular nucleus of the rat. A light and electron microscopic immunocytochemical study.大鼠下丘脑室旁核中5-羟色胺能轴突与促肾上腺皮质激素释放因子（CRF）合成神经元的突触相互作用。光镜和电镜免疫细胞化学研究。
Histochemistry. 1987;86(6):541-9. doi: 10.1007/BF00489545.

引用本文的文献

1
Glucocorticoid receptor signaling contributes to constitutive activation of the noncanonical NF-κB pathway in term human placenta.糖皮质激素受体信号传导有助于足月人胎盘中非经典核因子κB途径的组成性激活。
Mol Endocrinol. 2013 Feb;27(2):203-11. doi: 10.1210/me.2012-1309. Epub 2012 Dec 13.
2
Rapid neuromodulation by cortisol in the rat paraventricular nucleus: an in vitro study.皮质醇对大鼠室旁核的快速神经调节：一项体外研究。
Br J Pharmacol. 2002 Sep;137(1):87-97. doi: 10.1038/sj.bjp.0704832.
3
Studies of the secretion of corticotropin-releasing factor and arginine vasopressin into the hypophysial-portal circulation of the conscious sheep. II. The central noradrenergic and neuropeptide Y pathways cause immediate and prolonged hypothalamic-pituitary-adrenal activation. Potential involvement in the pseudo-Cushing's syndrome of endogenous depression and anorexia nervosa.
清醒绵羊垂体门脉循环中促肾上腺皮质激素释放因子和精氨酸加压素分泌的研究。II. 中枢去甲肾上腺素能和神经肽Y通路导致下丘脑-垂体-肾上腺立即和长期激活。可能参与内源性抑郁和神经性厌食的假性库欣综合征。
J Clin Invest. 1994 Apr;93(4):1439-50. doi: 10.1172/JCI117121.
4
Prednisolone excitation of medial vestibular nucleus neurons in cats.猫体内泼尼松龙对内侧前庭核神经元的刺激作用
Eur Arch Otorhinolaryngol. 1995;252(2):112-8. doi: 10.1007/BF00168032.
5
Catecholamine distribution and relationship to magnocellular neurons in the paraventricular nucleus of the rat.大鼠室旁核中儿茶酚胺的分布及其与大细胞神经元的关系
Cell Tissue Res. 1987 May;248(2):239-46. doi: 10.1007/BF00218190.
6
Adrenergic innervation of corticotropin releasing factor (CRF)-synthesizing neurons in the hypothalamic paraventricular nucleus of the rat. A combined light and electron microscopic immunocytochemical study.
Histochemistry. 1986;84(3):201-5. doi: 10.1007/BF00495783.
7
Ultrastructural localization of glucocorticoid receptor (GR) in hypothalamic paraventricular neurons synthesizing corticotropin releasing factor (CRF).在下丘脑合成促肾上腺皮质激素释放因子（CRF）的室旁核神经元中糖皮质激素受体（GR）的超微结构定位。
Histochemistry. 1987;87(5):407-12. doi: 10.1007/BF00496811.
8
Regulation of neuropeptide gene expression by steroid hormones.类固醇激素对神经肽基因表达的调控。
Mol Neurobiol. 1988 Fall;2(3):183-200. doi: 10.1007/BF02935345.
9
Glucocorticoid receptor immunoreactivity in monoaminergic neurons of rat brain.大鼠脑单胺能神经元中的糖皮质激素受体免疫反应性
Proc Natl Acad Sci U S A. 1986 Dec;83(24):9779-83. doi: 10.1073/pnas.83.24.9779.
10
Electron microscopic analysis of tyrosine hydroxylase, dopamine-beta-hydroxylase and phenylethanolamine-N-methyltransferase immunoreactive innervation of the hypothalamic paraventricular nucleus in the rat.大鼠下丘脑室旁核酪氨酸羟化酶、多巴胺-β-羟化酶和苯乙醇胺-N-甲基转移酶免疫反应性神经支配的电子显微镜分析
Histochemistry. 1986;84(2):105-20. doi: 10.1007/BF00499821.