Cintra A, Fuxe K, Härfstrand A, Agnati L F, Wikström A C, Okret S, Vale W, Gustafsson J A
Neurosci Lett. 1987 Jun 1;77(1):25-30. doi: 10.1016/0304-3940(87)90601-x.
By means of the indirect immunoperoxidase technique using two-color immunocytochemistry a moderate to strong nuclear glucocorticoid receptor (GR) immunoreactivity was demonstrated in the vast majority of the corticotrophin-releasing factor (CRF)-immunoreactive nerve cells of the parvocellular parts of the paraventricular hypothalamic nucleus, of the septohypothalamic nucleus, of the bed nucleus striae terminalis and of the central and medial amygdaloid nuclei. All the growth hormone-releasing factor (GRF)-immunoreactive nerve cells of the lateral magnocellular part of the arcuate nucleus in its entire rostrocaudal extent showed a moderate GR immunoreactivity. These results and others indicate that glucocorticoids may directly affect all the CRF and GRF cell populations projecting into the median eminence as well as CRF and GRF neurons controlling behavioral and autonomic functions.
通过使用双色免疫细胞化学的间接免疫过氧化物酶技术，在下丘脑室旁核小细胞部、隔下丘脑核、终纹床核以及杏仁中央核和内侧核的绝大多数促肾上腺皮质激素释放因子（CRF）免疫反应性神经细胞中，均显示出中度至强烈的核糖皮质激素受体（GR）免疫反应性。弓状核外侧大细胞部整个 rostrocaudal 范围内的所有生长激素释放因子（GRF）免疫反应性神经细胞均显示出中度 GR 免疫反应性。这些结果以及其他结果表明，糖皮质激素可能直接影响投射到正中隆起的所有 CRF 和 GRF 细胞群体，以及控制行为和自主功能的 CRF 和 GRF 神经元。
