Scutca Alexandra-Cristina, Jugănaru Iulius, Nicoară Delia-Maria, Brad Giorgiana-Flavia, Bugi Meda-Ada, Asproniu Raluca, Cristun Lucian-Ioan, Mărginean Otilia
Department XI Pediatrics, Discipline I Pediatrics, 'Victor Babeş' University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania.
Department of Pediatrics I, Children's Emergency Hospital "Louis Turcanu", 300011 Timisoara, Romania.
J Clin Med. 2024 Apr 27;13(9):2582. doi: 10.3390/jcm13092582.
(1) : Although most cases of new-onset type 1 diabetes mellitus (T1DM) are managed without serious events, life-threatening complications do arise in a subset of patients. Our objective was to assess the correlation between elevated SIRI values and adverse events related to the onset of T1DM. (2) This retrospective study, spanning ten years, included 187 patients with new-onset T1DM divided into three groups based on SIRI tertiles. The primary outcome was the occurrence of acute complications during hospital admission, while the secondary outcome was prolonged Intensive Care Unit (ICU) admission. (3) Patients with high SIRI values were more likely to experience higher disease activity, leading to longer ICU admission times and more frequent complications. Multivariate logistic regression analysis revealed that the SIRI was independently associated with acute complications ( = 0.003) and prolonged ICU length of stay ( = 0.003). Furthermore, receiver operating characteristic analysis demonstrated the SIRI's superior predictive accuracy compared to venous pH (AUC = 0.837 and AUC = 0.811, respectively) and to the individual component cell lineages of the SIRI. (4) These findings emphasize the potential utility of the SIRI as a prognostic marker in identifying patients at increased risk during T1DM hospital admissions.
(1)：虽然大多数新发1型糖尿病（T1DM）病例在治疗过程中未发生严重事件，但仍有一部分患者会出现危及生命的并发症。我们的目的是评估升高的SIRI值与T1DM发病相关不良事件之间的相关性。(2)这项为期十年的回顾性研究纳入了187例新发T1DM患者，根据SIRI三分位数分为三组。主要结局是住院期间急性并发症的发生，次要结局是重症监护病房（ICU）住院时间延长。(3)SIRI值高的患者更有可能经历更高的疾病活动度，导致更长的ICU住院时间和更频繁的并发症。多因素逻辑回归分析显示，SIRI与急性并发症（P = 0.003）和ICU住院时间延长（P = 0.003）独立相关。此外，受试者工作特征分析表明，与静脉血pH值（AUC分别为0.837和0.811）以及SIRI的各个组成细胞谱系相比，SIRI具有更高的预测准确性。(4)这些发现强调了SIRI作为一种预后标志物在识别T1DM住院期间风险增加患者方面的潜在效用。
