Gill P S, Levine A M, Meyer P R, Boswell W D, Burkes R L, Parker J W, Hofman F M, Dworsky R L, Lukes R J
Am J Med. 1985 May;78(5):742-8. doi: 10.1016/0002-9343(85)90277-3.
Primary central nervous system lymphoma constitutes one of the criteria for the acquired immune deficiency syndrome (AIDS), yet a paucity of information is currently available regarding the clinical, immunologic, or pathologic features of these patients. Six homosexual men presenting with primary central nervous system lymphoma were evaluated. Five of these patients presented with altered mental status. All lymphomas were intracranial. B cell immunoblastic sarcoma was found in five. Immune phenotyping studies performed in five patients revealed monoclonal lambda light chain in three, whereas one expressed only IgG heavy chain, and one demonstrated another B cell (LN-1) surface antigen. Hypodense, contrast-enhancing lesions were apparent on computed axial tomographic scanning of the brain, in sharp contrast to isodense or hyperdense lesions reported in primary central nervous system lymphomas without underlying immunodeficiency. Immunologic abnormalities in these patients were similar to those in AIDS presenting as Kaposi's sarcoma or with opportunistic infections. In spite of therapeutic interventions, survival was short, and only one patient is currently alive.
原发性中枢神经系统淋巴瘤是获得性免疫缺陷综合征（艾滋病）的诊断标准之一，但目前关于这些患者的临床、免疫或病理特征的信息较少。对6例患有原发性中枢神经系统淋巴瘤的同性恋男性进行了评估。其中5例患者出现精神状态改变。所有淋巴瘤均位于颅内。5例为B细胞免疫母细胞肉瘤。对5例患者进行的免疫表型研究显示，3例有单克隆λ轻链，1例仅表达IgG重链，1例显示另一种B细胞（LN-1）表面抗原。脑部计算机断层扫描显示低密度、强化病变，这与无潜在免疫缺陷的原发性中枢神经系统淋巴瘤所报告的等密度或高密度病变形成鲜明对比。这些患者的免疫异常与表现为卡波西肉瘤或机会性感染的艾滋病患者相似。尽管进行了治疗干预，患者生存期仍较短，目前仅1例患者存活。
