Akıdan Melih, Erol Muhammet Kazım, Gedik Birumut, Doğan Mehmet Erkan, Başol Ibrahim, Süren Elçin
Department of Ophthalmology, Antalya Akseki State Hospital, 07630 Antalya, Turkey.
Department of Ophthalmology, Antalya Training and Research Hospital, University of Health Sciences, 07100 Antalya, Turkey.
Diagnostics (Basel). 2024 Apr 23;14(9):874. doi: 10.3390/diagnostics14090874.
we aimed to report on the optical coherence tomography angiography (OCTA) outcomes of eight patients with optic disc pit maculopathy (ODP-M) who were treated with 23-gauge pars plana vitrectomy (PPV).
We examined sixteen eyes of eight patients-eight eyes with ODP-M and eight healthy fellow eyes. Fundus color photography, fundus autofluorescence, fundus fluorescein angiography, optical coherence tomography (OCT), and OCTA were performed. The vascular density, choriocapillaris blood flow (CCBF), and foveal avascular zone (FAZ) were analyzed using OCTA. Moreover, the correlation between the best-corrected visual acuity (BCVA) and macular OCTA parameters was assessed.
Compared with the healthy fellow eyes, the eyes with ODP-M preoperatively were found to have decreased BCVA, superficial capillary plexus (SCP) vascular density (i.e., total, foveal, parafoveal, and perifoveal), deep capillary plexus (DCP) vascular density (i.e., total, parafoveal, and perifoveal), and CCBF but a significantly increased FAZ ( < 0.05). When the eyes with ODP-M were analyzed pre- and postoperatively at month 12 after surgery, the BCVA, SCP vascular density (i.e., perifoveal), and CCBF had significantly increased, and the FAZ had significantly decreased ( < 0.05). When the eyes with ODP-M were compared with the healthy fellow eyes postoperatively at month 12, the BCVA, SCP, and DCP vascular density parameters had increased, along with CCBF, and the FAZ had decreased in eyes with ODP-M, though not to the levels of the healthy fellow eyes ( < 0.05). Moreover, a positive correlation was found between the postoperative BCVA and SCP total vascular density ( < 0.05).
The BCVA and macular OCTA parameters improved in eyes with ODP-M at month 12 following surgery. However, the BCVA and OCTA of the eyes operated on did not reach the levels of the healthy fellow eyes, possibly due to impaired choroidal blood flow (CBF) recovery and the presence of a larger FAZ. In summary, OCTA seems to be useful for assessing qualitative and quantitative perioperative microvascular changes.
我们旨在报告8例视盘小凹黄斑病变（ODP-M）患者接受23G经睫状体平坦部玻璃体切除术（PPV）后的光学相干断层扫描血管造影（OCTA）结果。
我们检查了8例患者的16只眼——8只ODP-M患眼和8只健康对侧眼。进行了眼底彩色照相、眼底自发荧光、眼底荧光血管造影、光学相干断层扫描（OCT）和OCTA检查。使用OCTA分析血管密度、脉络膜毛细血管血流（CCBF）和黄斑无血管区（FAZ）。此外，评估了最佳矫正视力（BCVA）与黄斑OCTA参数之间的相关性。
与健康对侧眼相比，术前ODP-M患眼的BCVA、浅表毛细血管丛（SCP）血管密度（即总密度、黄斑中心凹、黄斑旁和黄斑周围）、深部毛细血管丛（DCP）血管密度（即总密度、黄斑旁和黄斑周围）和CCBF降低，但FAZ显著增加（<0.05）。对ODP-M患眼在术后12个月进行术前和术后分析时，BCVA、SCP血管密度（即黄斑周围）和CCBF显著增加，FAZ显著降低（<0.05）。将术后12个月的ODP-M患眼与健康对侧眼进行比较时，ODP-M患眼的BCVA、SCP和DCP血管密度参数以及CCBF增加，FAZ降低，尽管未降至健康对侧眼的水平（<0.05）。此外，术后BCVA与SCP总血管密度之间存在正相关（<0.05）。
ODP-M患眼在术后12个月时BCVA和黄斑OCTA参数有所改善。然而，手术眼的BCVA和OCTA未达到健康对侧眼的水平，可能是由于脉络膜血流（CBF）恢复受损和存在较大的FAZ。总之，OCTA似乎有助于评估围手术期微血管的定性和定量变化。
