University of Health Sciences, Antalya Education and Research Hospital, Department of Ophthalmology, Antalya, Turkey.
University of Health Sciences, Antalya Education and Research Hospital, Department of Ophthalmology, Antalya, Turkey.
Photodiagnosis Photodyn Ther. 2021 Sep;35:102428. doi: 10.1016/j.pdpdt.2021.102428. Epub 2021 Jul 1.
A macular hole (MH) is a defect that occurs in the retina and involves all layers. In this study, we aimed to investigate the preoperative and postoperative choriocapillaris blood flow (CBF) changes in patients with MH and the role of CBF in the pathogenesis of the disease using optical coherence tomography angiography (OCTA).
This is a retrospective study examining eyes with MH. The study included 25 operated eyes of 25 patients and contralateral eyes of 18 patients. CBF and subfoveal choroidal thickness were examined using the OCTA images of the patients before surgery and at the first, third and sixth months after surgery.
The mean CBF value of the patients was 1.57±0.20 mm² preoperatively, 1.94±0.13 mm² at the postoperative first month, 1.98±0.12 mm² at the third month, and 2.00±0.10 mm² at the sixth month. The increases in the CBF values between the preoperative period and the postoperative measurements were statistically significant (p<0.0001 for all). In the preoperative period, the CBF value of the contralateral eyes was 2.07±0.10 mm². The preoperative CBF value of the contralateral eyes was higher compared to that of the eyes with MH (p<0.0001). There was no significant difference between the preoperative CBF value of the contralateral eyes and the postoperative sixth-month value of the eyes with MH (p = 0.065).
The preoperative and postoperative third-month CBF values of the eyes with MH were found to be lower than those of the contralateral eyes, but there was no difference between the postoperative sixth-month CBF value of the eyes with MH and the preoperative CBF value of the contralateral eyes. We consider that the eyes with MH achieve similar CBF values to the contralateral eyes in an average of six months after successful surgery.
黄斑裂孔（MH）是一种发生在视网膜并累及所有层的缺陷。在这项研究中，我们旨在使用光相干断层扫描血管造影术（OCTA）研究 MH 患者术前和术后脉络膜毛细血管血流（CBF）的变化，并探讨 CBF 在疾病发病机制中的作用。
这是一项回顾性研究，研究对象为 MH 患者。该研究纳入了 25 例 25 只手术眼和 18 例患者的对侧眼。在手术前和手术后第 1、3 和 6 个月，使用 OCTA 图像检查患者的 CBF 和中心凹下脉络膜厚度。
患者术前平均 CBF 值为 1.57±0.20mm²，术后第 1 个月为 1.94±0.13mm²，第 3 个月为 1.98±0.12mm²，第 6 个月为 2.00±0.10mm²。术前与术后各测量值之间的 CBF 值增加均具有统计学意义（p<0.0001）。在术前，对侧眼的 CBF 值为 2.07±0.10mm²。与 MH 眼相比，术前对侧眼的 CBF 值更高（p<0.0001）。MH 眼术前 CBF 值与术后第 6 个月的 CBF 值之间无显著差异（p=0.065）。
MH 眼的术前和术后第 3 个月的 CBF 值均低于对侧眼，但 MH 眼术后第 6 个月的 CBF 值与对侧眼的术前 CBF 值无差异。我们认为，MH 眼在手术后平均 6 个月内可达到与对侧眼相似的 CBF 值。
