Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 61000, Sichuan Province, China.
Int Arch Occup Environ Health. 2024 Aug;97(6):621-639. doi: 10.1007/s00420-024-02072-0. Epub 2024 May 11.
Metabolic Syndrome (MetS) is a widely observed metabolic disorder that is increasingly prevalent worldwide, leading to substantial societal consequences. Previous studies have conducted two separate meta-analyses to investigate the relationship between MetS and air pollutants. However, these studies yielded conflicting results, necessitating a thorough systematic review and meta-analysis to reassess the link between different air pollutants and the risk of developing MetS.
We conducted a comprehensive search of relevant literature in databases including PubMed, Embase, Cochrane Library, and Web of Science up to October 9, 2023. The search was specifically restricted to publications in the English language. Following the screening of studies investigating the correlation between air pollution and MetS, we utilized random-effects models to calculate pooled effect sizes along with their respective 95% confidence intervals (CIs). We would like to highlight that this study has been registered with PROSPERO, and it can be identified by the registration number CRD42023484421.
The study included twenty-four eligible studies. The results revealed that an increase of 10 μg/m in annual concentrations of PM, PM, PM, NO, SO, and O was associated with a 29% increase in metabolic syndrome (MetS) risk for PM1 (OR = 1.29 [CI 1.07-1.54]), an 8% increase for PM2.5 (OR = 1.08 [CI 1.06-1.10]), a 17% increase for PM (OR = 1.17 [CI 1.08-1.27]), a 24% increase for NO (OR = 1.24 [CI 1.01-1.51]), a 19% increase for SO (OR = 1.19 [CI 1.04-1.36]), and a 10% increase for O (OR = 1.10 [CI 1.07-1.13]).
The findings of this study demonstrate a significant association between exposure to fine particulate matter (PM, PM, PM), nitrogen dioxide (NO), sulfur dioxide (SO), ozone (O), and the incidence of metabolic syndrome (MetS). Moreover, the results suggest that air pollution exposure could potentially contribute to the development of MetS in humans.
代谢综合征（MetS）是一种广泛观察到的代谢紊乱，在全球范围内日益普遍，给社会带来了重大后果。先前的研究已经进行了两项单独的荟萃分析来研究代谢综合征与空气污染物之间的关系。然而，这些研究的结果相互矛盾，因此需要进行全面的系统回顾和荟萃分析，以重新评估不同空气污染物与代谢综合征风险之间的联系。
我们在包括 PubMed、Embase、Cochrane Library 和 Web of Science 在内的数据库中进行了全面的文献搜索，截至 2023 年 10 月 9 日。搜索仅限于发表在英语中的出版物。在筛选了研究空气污染与代谢综合征之间相关性的研究后，我们使用随机效应模型计算了汇总效应大小及其各自的 95%置信区间（CI）。我们想强调的是，这项研究已经在 PROSPERO 上注册，它可以通过注册号 CRD42023484421 来识别。
该研究纳入了 24 项符合条件的研究。结果表明，每年 PM、PM、PM、NO、SO 和 O 浓度增加 10μg/m，代谢综合征（MetS）的风险增加 29%（PM1 的 OR=1.29[CI 1.07-1.54]），PM2.5 增加 8%（OR=1.08[CI 1.06-1.10]），PM 增加 17%（OR=1.17[CI 1.08-1.27]），NO 增加 24%（OR=1.24[CI 1.01-1.51]），SO 增加 19%（OR=1.19[CI 1.04-1.36]），O 增加 10%（OR=1.10[CI 1.07-1.13]）。
这项研究的结果表明，细颗粒物（PM、PM、PM）、二氧化氮（NO）、二氧化硫（SO）、臭氧（O）暴露与代谢综合征（MetS）的发生之间存在显著关联。此外，结果表明，空气污染暴露可能会导致人类代谢综合征的发生。
