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本文引用的文献

1
Anti-seizure gene therapy for focal cortical dysplasia.抗癫痫基因治疗局灶性皮质发育不良。
Brain. 2024 Feb 1;147(2):542-553. doi: 10.1093/brain/awad387.
2
Excitatory somatostatin interneurons in the dentate gyrus drive a widespread seizure network in cortical dysplasia.齿状回中的兴奋性生长抑素中间神经元驱动皮质发育不良中的广泛癫痫网络。
Signal Transduct Target Ther. 2023 May 17;8(1):186. doi: 10.1038/s41392-023-01404-9.
3
On-demand cell-autonomous gene therapy for brain circuit disorders.按需细胞自主基因治疗脑回路疾病。
Science. 2022 Nov 4;378(6619):523-532. doi: 10.1126/science.abq6656. Epub 2022 Nov 3.
4
Subicular Caspase-1 Contributes to Pharmacoresistance in Temporal Lobe Epilepsy.内侧齿状回 Caspase-1 参与颞叶癫痫的药物抵抗。
Ann Neurol. 2021 Sep;90(3):377-390. doi: 10.1002/ana.26173. Epub 2021 Aug 11.
5
Epilepsy in patients with focal cortical dysplasia may be associated with autism spectrum disorder.局灶性皮质发育不良患者的癫痫可能与自闭症谱系障碍有关。
Epilepsy Behav. 2021 Jul;120:107990. doi: 10.1016/j.yebeh.2021.107990. Epub 2021 May 3.
6
In vivo CRISPRa decreases seizures and rescues cognitive deficits in a rodent model of epilepsy.体内 CRISPRa 减少癫痫啮齿动物模型中的癫痫发作并挽救认知缺陷。
Brain. 2020 Mar 1;143(3):891-905. doi: 10.1093/brain/awaa045.
7
Epilepsy Gene Therapy Using an Engineered Potassium Channel.癫痫的基因治疗：利用工程化钾离子通道
J Neurosci. 2019 Apr 17;39(16):3159-3169. doi: 10.1523/JNEUROSCI.1143-18.2019. Epub 2019 Feb 12.
8
Convulsive seizures from experimental focal cortical dysplasia occur independently of cell misplacement.实验性局灶性皮质发育不良引起的惊厥发作与细胞错位无关。
Nat Commun. 2016 Jun 1;7:11753. doi: 10.1038/ncomms11753.
9
Brain somatic mutations in MTOR cause focal cortical dysplasia type II leading to intractable epilepsy.MTOR 中的脑体细胞突变导致 II 型局灶性皮质发育不良，进而引发难治性癫痫。
Nat Med. 2015 Apr;21(4):395-400. doi: 10.1038/nm.3824. Epub 2015 Mar 23.
10
The clinicopathologic spectrum of focal cortical dysplasias: a consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission.局灶性皮质发育不良的临床病理谱：国际抗癫痫联盟诊断方法委员会特别工作组提出的共识分类。
Epilepsia. 2011 Jan;52(1):158-74. doi: 10.1111/j.1528-1167.2010.02777.x. Epub 2010 Nov 10.

Raising New Hope for Controlling Seizures in Focal Cortical Dysplasia with Gene Therapy.

作者信息

Yang Yuanzhi, Zheng Yang, Chen Zhong, Xu Cenglin

机构信息

Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Sciences, Xinhua Hospital of Zhejiang Province, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang Chinese Medical University, Hangzhou, 310053, China.

出版信息

Neurosci Bull. 2024 Jul;40(7):1028-1030. doi: 10.1007/s12264-024-01212-3. Epub 2024 May 11.

DOI:10.1007/s12264-024-01212-3
PMID:38733552
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11250706/
Abstract
摘要