Comprehensive Epilepsy Center, Seirei Hamamatsu General Hospital, Shizuoka, Japan; Seirei Christopher University, Shizuoka, Japan.
Comprehensive Epilepsy Center, Seirei Hamamatsu General Hospital, Shizuoka, Japan.
Epilepsy Behav. 2021 Jul;120:107990. doi: 10.1016/j.yebeh.2021.107990. Epub 2021 May 3.
Patients with epilepsy associated with focal cortical dysplasia (FCD) may be associated with autism spectrum disorder (ASD). Therefore, the purpose of this study was to compare surgically treated patients with epilepsy secondary to FCD and normal volunteers without epilepsy and to review the neuropathological findings of patients with FCD.
This study involved 38 patients with medically intractable focal onset epileptic seizures who underwent epilepsy surgery (Group 1). All patients had epilepsy associated with FCD. These patients and 38 normal volunteers without epilepsy (Group 2) were administered the autism spectrum quotient (AQ) test, and the groups were compared.
The 38 patients in Group 1 included 16 females and 22 males (age range 20-60, mean age, 33.0; standard deviation (SD), 11.8 years). The normal volunteers in Group 2 included 22 females and 16 males (age range 20-57, mean age, 30.6 years; SD, 8.8 years). Total AQ scores were significantly higher in Group 1 than Group 2 (p = 0.027). Patients with FCD I showed a higher AQ score than those with FCD II in the AQ test (p ≤ 0.001).
Patients with epilepsy secondary to FCD were associated with higher ASD score than normal volunteers. This tendency was seen more strongly in patients with FCD I than FCD II.
伴局灶性皮质发育不良（FCD）的癫痫患者可能与自闭症谱系障碍（ASD）相关。因此，本研究的目的是比较继发于 FCD 的癫痫手术治疗患者和无癫痫的正常志愿者，并回顾 FCD 患者的神经病理学发现。
本研究纳入了 38 例接受癫痫手术的药物难治性局灶性起始癫痫发作患者（第 1 组）。所有患者均伴有 FCD 相关癫痫。对这些患者和 38 名无癫痫的正常志愿者（第 2 组）进行自闭症谱系商数（AQ）测试，并对两组进行比较。
第 1 组 38 例患者中，女性 16 例，男性 22 例（年龄 20-60 岁，平均年龄 33.0 岁，标准差 11.8 岁）。第 2 组 38 名正常志愿者中，女性 22 名，男性 16 名（年龄 20-57 岁，平均年龄 30.6 岁，标准差 8.8 岁）。第 1 组的总 AQ 评分明显高于第 2 组（p=0.027）。在 AQ 测试中，FCD I 型患者的 AQ 评分高于 FCD II 型患者（p≤0.001）。
继发于 FCD 的癫痫患者的 ASD 评分高于正常志愿者。FCD I 型患者比 FCD II 型患者表现出更强的这种趋势。
