Cell Signalling and Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Cell Signalling and Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Curr Opin Immunol. 2024 Apr;87:102421. doi: 10.1016/j.coi.2024.102421. Epub 2024 May 10.
Effective high-affinity, long-term humoral immunity requires T cell help provided by a subset of differentiated CD4 T cells known as T follicular helper (Tfh) cells. Classically, Tfh cells provide contact-dependent help for the generation of germinal centers (GCs) in secondary lymphoid organs (SLOs). Recent studies have expanded the conventional definition of Tfh cells, revealing new functions, new descriptions of Tfh subsets, new factors regulating Tfh differentiation, and new roles outside of SLO GCs. Together, these data suggest that one Tfh is not equivalent to another, helping redefine our understanding of Tfh cells and their biology.
有效的高亲和力、长期体液免疫需要 T 细胞辅助，由称为滤泡辅助 T 细胞（Tfh）的分化 CD4 T 细胞亚群提供。传统上，Tfh 细胞为次级淋巴器官（SLO）中生发中心（GC）的产生提供接触依赖性帮助。最近的研究扩展了 Tfh 细胞的传统定义，揭示了 Tfh 细胞的新功能、新的 Tfh 亚群描述、调节 Tfh 分化的新因子以及 SLO GC 之外的新作用。这些数据共同表明，一个 Tfh 细胞不等同于另一个 Tfh 细胞，有助于重新定义我们对 Tfh 细胞及其生物学的理解。
