滤泡辅助性 T 细胞分化在抗肿瘤免疫中的调控。
Regulation of follicular T helper cell differentiation in antitumor immunity.
机构信息
Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, College of Life Sciences, Beijing Normal University, Beijing, China.
State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
出版信息
Int J Cancer. 2023 Jul 15;153(2):265-277. doi: 10.1002/ijc.34368. Epub 2022 Nov 28.
Follicular T helper (Tfh) cells are a subset of CD4 T cells that play an important role in the formation of germinal centers and the maturation and differentiation of affinity-matured B cells. Recent studies have demonstrated important functions of Tfh cells in tertiary lymphoid structures of tumors, revealing great potential of Tfh cells in tumor immunity. However, Tfh development is incompletely understood. The differentiation of Tfh cells is a complex, multistage process regulated at the DNA, RNA and protein levels. This review just summarizes current research on the molecular mechanisms of Tfh cell differentiation to better understand the role of Tfh cells in antitumor immunity.
滤泡辅助性 T 细胞（Tfh）是 CD4 T 细胞的一个亚群，在生发中心的形成以及亲和力成熟 B 细胞的成熟和分化中发挥重要作用。最近的研究表明，Tfh 细胞在肿瘤的三级淋巴结构中具有重要功能，揭示了 Tfh 细胞在肿瘤免疫中的巨大潜力。然而，Tfh 的分化机制尚不完全清楚。Tfh 细胞的分化是一个复杂的、多阶段的过程，在 DNA、RNA 和蛋白质水平受到调节。本综述仅总结了 Tfh 细胞分化的分子机制的最新研究，以更好地理解 Tfh 细胞在抗肿瘤免疫中的作用。
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