Laboratory of Aging Research and Cancer Drug Target, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, No. 17, Block 3, Southern Renmin Road, 610041 Chengdu, Sichuan, PR China.
Laboratory of Aging Research and Cancer Drug Target, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, No. 17, Block 3, Southern Renmin Road, 610041 Chengdu, Sichuan, PR China.
Biochim Biophys Acta Rev Cancer. 2024 Jul;1879(4):189107. doi: 10.1016/j.bbcan.2024.189107. Epub 2024 May 9.
The functions of mitochondria, including energy production and biomolecule synthesis, have been known for a long time. Given the rising incidence of cancer, the role of mitochondria in cancer has become increasingly popular. Activated by components released by mitochondria, various pathways interact with each other to induce immune responses to protect organisms from attack. However, mitochondria play dual roles in the progression of cancer. Abnormalities in proteins, which are the elementary structures of mitochondria, are closely linked with oncogenesis. Both the aberrant accumulation of intermediates and mutations in enzymes result in the generation and progression of cancer. Therefore, targeting mitochondria to treat cancer may be a new strategy. Several drugs aimed at inhibiting mutated enzymes and accumulated intermediates have been tested clinically. Here, we discuss the current understanding of mitochondria in cancer and the interactions between mitochondrial functions, immune responses, and oncogenesis. Furthermore, we discuss mitochondria as hopeful targets for cancer therapy, providing insights into the progression of future therapeutic strategies.
线粒体的功能，包括能量产生和生物分子合成，早已为人所知。鉴于癌症发病率的上升，线粒体在癌症中的作用变得越来越受欢迎。各种途径被线粒体释放的成分激活，相互作用诱导免疫反应，保护机体免受攻击。然而，线粒体在癌症的进展中发挥着双重作用。线粒体的基本结构——蛋白质的异常与致癌密切相关。中间产物的异常积累和酶的突变都会导致癌症的发生和发展。因此，靶向线粒体治疗癌症可能是一种新的策略。几种旨在抑制突变酶和积累中间产物的药物已在临床上进行了测试。在这里，我们讨论了目前对癌症中线粒体的认识，以及线粒体功能、免疫反应和致癌之间的相互作用。此外，我们还讨论了线粒体作为癌症治疗有希望的靶点，为未来治疗策略的进展提供了思路。
