Tawn E J, Hall J W, Schofield G B
Int J Radiat Biol Relat Stud Phys Chem Med. 1985 May;47(5):599-610. doi: 10.1080/09553008514550831.
Chromosome analyses have been performed on peripheral blood lymphocytes from 54 men with estimates of plutonium body burdens in excess of 296 Bq. Both stable and unstable aberrations were scored using a banding technique and breakpoints noted. In discussing the significance of aberration frequencies the relative proportions of the different types of aberration and their distribution have been considered and account has been taken of external radiation exposure. It is suggested that significant depositions of plutonium do cause an increase in chromosome aberrations. The distribution of the breakpoints in the controls showed an excess in chromosomes 7 and 14. The formation and survival of radiation-induced breakpoints was randomly distributed amongst the chromosomes according to length. The distribution of the breakpoints within the chromosomes showed an excess in the centromeres and telomeres. Possible hot spots occurred in some of these regions and also in certain bands of the intermediate regions of the chromosomes.
对54名钚体内负荷估计超过296贝克勒尔的男性外周血淋巴细胞进行了染色体分析。使用显带技术对稳定和不稳定畸变进行评分，并记录断点。在讨论畸变频率的意义时，考虑了不同类型畸变的相对比例及其分布，并考虑了外部辐射暴露情况。研究表明，钚的大量沉积确实会导致染色体畸变增加。对照组断点在7号和14号染色体上出现过多。辐射诱导断点的形成和存活根据长度随机分布在各染色体之间。染色体内部断点的分布在着丝粒和端粒处出现过多。在这些区域中的一些以及染色体中间区域的某些带中可能存在热点。
