Neel J V, Awa A A, Kodama Y, Nakano M, Mabuchi K
Department of Human Genetics, University of Michigan, Ann Arbor 48109-0618.
Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):6973-7. doi: 10.1073/pnas.89.15.6973.
Cultured lymphocytes exhibiting extreme cytogenetic damage (rogue cells) were observed in preparations from 8 of 24 individuals sampled in Krasilovka, a Ukrainian village receiving little or no increased radiation after the Chernobyl disaster, but were not observed in an additional 24 persons from two Russian towns in the more contaminated area. This observation cements the worldwide occurrence of these cells. The present data plus a review of the literature establish that rogue cells appear in brief bursts simultaneously in certain individuals of discrete populations. We suggest that the pattern is consistent with the action of a viral trigger that acts directly or indirectly--the latter possibly through the activation of latent chromosomal retroposons. If this phenomenon occurs in other tissues, it may have important implications for oncogenesis, teratogenesis, mutagenesis, and evolution.
在乌克兰村庄克拉西洛夫卡采集的24份样本中，有8份样本的细胞培养淋巴细胞出现了极端的细胞遗传学损伤（异常细胞）。切尔诺贝利灾难后，该村庄几乎没有或没有受到额外辐射。但在污染更严重地区的两个俄罗斯城镇的另外24人中未观察到这种情况。这一观察结果证实了这些细胞在全球范围内的存在。目前的数据加上文献综述表明，异常细胞会在离散人群的某些个体中同时短暂爆发。我们认为，这种模式与病毒触发因素的作用一致，该触发因素直接或间接起作用——后者可能是通过激活潜伏的染色体逆转座子。如果这种现象发生在其他组织中，可能对肿瘤发生、致畸、诱变和进化具有重要意义。
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