Panagiotakos Demosthenes, Sigala Evangelia G, Damigou Evangelia, Loukina Asimina, Dalmyras Dimitriοs, Mentzantonakis Georgios, Barkas Fotios, Adamidis Petros S, Kravvariti Evrydiki, Liberopoulos Evangelos, Sfikakis Petros P, Tsioufis Costas, Pitsavos Christos, Chrysohoou Christina
Department of Nutrition and Dietetics, School of Health Sciences and Education, Harokopio University, Athens 17671, Greece.
Department of Nutrition and Dietetics, School of Health Sciences and Education, Harokopio University, Athens 17671, Greece.
Hellenic J Cardiol. 2024 May 10. doi: 10.1016/j.hjc.2024.05.009.
The aim of this study was to present the burden of cardiovascular disease (CVD) and its related risk factors based on a 20-year observation period (2002-2022).
In 2002, 3042 Greek adults (aged: 45 (12) years) free of CVD, cancer, or any other chronic infections were enrolled. In 2022, the 20-year follow-up was performed on 2169 participants (1988 had complete data for CVD). Lifetime risk for CVDs and disability-adjusted-life-years (DALYs) lost were also calculated.
The 20-year CVD incidence was 3600 cases/10,000 individuals (man-to-woman ratio 5:4). At the index age of 40 years, the lifetime risk for developing CVD was 68% for men and 63% for women; as the participants were getting older, the lifetime risk declined by approximately 19% and 13% for men and women, respectively, but remained at high levels, reaching 55% for both sexes. Participants between 45 and 55 years exhibited the highest CVD burden concerning aggregated DALYs. The burden was greater in men than in women, at ages below 35 years; beyond this age threshold, this trend shifted, and women exhibited a higher CVD burden.
The burden of CVD in Greece has shown increasing trends over the past 20 years as a result of the accumulative growth of the prevalence of modifiable CVD risk factors. The disability-adjusted life-years lost are the most observed ever before, urging for efficient public health strategies and measures.
本研究旨在基于20年观察期（2002年至2022年）呈现心血管疾病（CVD）及其相关危险因素的负担情况。
2002年，招募了3042名无心血管疾病、癌症或任何其他慢性感染的希腊成年人（年龄：45（12）岁）。2022年，对2169名参与者进行了20年随访（1988人有完整的心血管疾病数据）。还计算了心血管疾病的终生风险和损失的伤残调整生命年（DALY）。
20年心血管疾病发病率为3600例/10000人（男女比例为5:4）。在40岁的索引年龄时，男性患心血管疾病的终生风险为68%，女性为63%；随着参与者年龄增长，男性和女性的终生风险分别下降了约19%和13%，但仍处于较高水平，两性均达到55%。45至55岁的参与者在汇总伤残调整生命年方面表现出最高的心血管疾病负担。在35岁以下，男性的负担大于女性；超过这个年龄阈值，这种趋势发生了变化，女性表现出更高的心血管疾病负担。
由于可改变的心血管疾病危险因素患病率的累积增长，希腊过去20年中心血管疾病负担呈上升趋势。损失的伤残调整生命年是有史以来观察到的最多的，这促使采取有效的公共卫生策略和措施。
