Pelotonia Research Center, Department of Horticulture and Crop Science, the Ohio State University, 2255 Kenny Rd, Columbus, OH 43210, USA.
Curr Opin Biotechnol. 2024 Jun;87:103142. doi: 10.1016/j.copbio.2024.103142. Epub 2024 May 11.
Plant synthetic biology has the capability to provide solutions to global challenges in the production and supply of medicines. Recent advances in 'omics' technologies have accelerated gene discoveries in medicinal plant research so that even multistep biosynthetic pathways for bioactive plant natural products with high structural complexity can be reconstituted in heterologous plant expression systems more rapidly. This review provides an overview of concept and strategies used to produce high-value plant natural products in heterologous plant systems and highlights recent successes in engineering the biosynthesis of conventional and new medicines in alternative plant hosts.
植物合成生物学有能力为药品生产和供应方面的全球性挑战提供解决方案。“组学”技术的最新进展加速了药用植物研究中的基因发现，使得具有高结构复杂性的生物活性植物天然产物的多步生物合成途径能够更快地在异源植物表达系统中重建。本文综述了在异源植物系统中生产高价值植物天然产物的概念和策略，并重点介绍了在替代植物宿主中工程化传统和新型药物生物合成的最新成功案例。
