草珊瑚种子中具有过氧桥的倍半萜-单萜共轭物——草珊瑚过氧化物A和B

Sarglaperoxides A and B, Sesquiterpene-Normonoterpene Conjugates with a Peroxide Bridge from the Seeds of Sarcandra glabra.

作者信息

Wang Peng, Li Rui-Jun, Liu Rui-Huan, Jian Kai-Li, Yang Ming-Hua, Yang Lei, Kong Ling-Yi, Luo Jun

机构信息

State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University , 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China.

School of Pharmacy, Yancheng Teachers University , Xiwang Road, Yancheng 224051, People's Republic of China.

出版信息

Org Lett. 2016 Feb 19;18(4):832-5. doi: 10.1021/acs.orglett.6b00112. Epub 2016 Jan 29.

DOI:10.1021/acs.orglett.6b00112

PMID:26824697

Abstract

Sarglaperoxides A (1) and B (2), a pair of unusual sesquiterpene-normonoterpene conjugates with a peroxide bridge, were isolated from the seeds of Sarcandra glabra. The structures and absolute configurations of 1 and 2 were determined on the basis of spectroscopic data analysis, including MS, NMR, CD, and XRD. The two compounds were screened in antimicrobial, anti-inflammatory, and cytotoxic bioassays and showed moderate bioactivities.

摘要

从九节龙种子中分离得到了一对具有过氧化物桥的不寻常倍半萜-单萜共轭物——萨格拉过氧化物A（1）和B（2）。基于质谱（MS）、核磁共振（NMR）、圆二色谱（CD）和X射线衍射（XRD）等光谱数据分析确定了1和2的结构及绝对构型。对这两种化合物进行了抗菌、抗炎和细胞毒性生物活性筛选，结果显示它们具有中等生物活性。