Laboratory of Neurosciences, Instituto Nacional de Pediatria, Mexico City, Mexico.
Laboratory of Experimental Bacteriology, Instituto Nacional de Pediatria, Mexico City, Mexico.
Sci Rep. 2024 May 12;14(1):10835. doi: 10.1038/s41598-024-61766-0.
Research on the relationships between oligoelements (OE) and the development of cancer or its prevention is a field that is gaining increasing relevance. The aim was to evaluate OE and their interactions with oncology treatments (cytarabine or etoposide) to determine the effects of this combination on biogenic amines and oxidative stress biomarkers in the brain regions of young Wistar rats. Dopamine (DA), 5-Hydroxyindoleacetic acid (5-Hiaa), Glutathione (Gsh), Tiobarbituric acid reactive substances (TBARS) and Ca, Mg ATPase enzyme activity were measured in brain regions tissues using spectrophometric and fluorometric methods previously validated. The combination of oligoelements and cytarabine increased dopamine in the striatum but decreased it in cerebellum/medulla-oblongata, whereas the combination of oligoelements and etoposide reduced lipid peroxidation. These results suggest that supplementation with oligoelements modifies the effects of cytarabine and etoposide by redox pathways, and may become promising therapeutic targets in patients with cancer.
研究微量元素 (OE) 与癌症发展或预防之间的关系是一个日益受到关注的领域。本研究旨在评估 OE 及其与肿瘤治疗（阿糖胞苷或依托泊苷）的相互作用，以确定这种组合对年轻 Wistar 大鼠脑区生物胺和氧化应激生物标志物的影响。使用先前经过验证的分光光度法和荧光法测量脑区组织中的多巴胺 (DA)、5-羟色氨酸乙酸 (5-Hiaa)、谷胱甘肽 (Gsh)、硫代巴比妥酸反应物质 (TBARS) 和 Ca、Mg ATP 酶活性。结果表明，OE 与阿糖胞苷的组合增加了纹状体中的多巴胺，但降低了小脑/延髓中的多巴胺，而 OE 与依托泊苷的组合降低了脂质过氧化。这些结果表明，OE 的补充通过氧化还原途径改变了阿糖胞苷和依托泊苷的作用，可能成为癌症患者有前途的治疗靶点。
