Dolezal Darin, Kholová Ivana, Cai Guoping
Department of Pathology, Yale School of Medicine, New Haven, Connecticut, USA.
Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
J Clin Transl Pathol. 2024 Jan-Mar;4(1):18-35. doi: 10.14218/jctp.2023.00068. Epub 2024 Mar 11.
The World Health Organization Reporting System for Lung Cytopathology is the first international system that was developed to standardize the reporting of lung cytopathology specimens across all settings of cytopathology practice. The system is composed of five diagnostic categories, which apply to all lung cytopathology specimen types. Each category contains cytomorphologic criteria, an estimated risk of malignancy, and clinical management recommendations. International uniformity in the reporting of lung cytopathology will refine the communication between cytopathologists and clinicians and ultimately improve patient care. Furthermore, standardizing the cytomorphologic criteria for each lesion will improve reproducibility among cytopathologists and highlight areas in lung cytopathology that require further research. The system also provides best practice recommendations for the selection of ancillary tests to aid in the diagnosis of each lesion, or group of lesions, keeping in mind that resources will vary across different practice settings. The goal of this review is to summarize the cytomorphologic criteria, potential diagnostic pitfalls, ancillary testing, estimated risk of malignancy, and clinical management recommendations for each diagnostic category.
世界卫生组织肺细胞病理学报告系统是首个为使所有细胞病理学实践环境中肺细胞病理学标本报告标准化而开发的国际系统。该系统由五个诊断类别组成，适用于所有肺细胞病理学标本类型。每个类别都包含细胞形态学标准、恶性肿瘤估计风险以及临床管理建议。肺细胞病理学报告的国际一致性将优化细胞病理学家与临床医生之间的沟通，并最终改善患者护理。此外，标准化每个病变的细胞形态学标准将提高细胞病理学家之间的可重复性，并突出肺细胞病理学中需要进一步研究的领域。该系统还为辅助检查的选择提供了最佳实践建议，以帮助诊断每个病变或一组病变，同时要记住不同实践环境中的资源会有所不同。本综述的目的是总结每个诊断类别的细胞形态学标准、潜在诊断陷阱、辅助检查、恶性肿瘤估计风险以及临床管理建议。
