Koutsogiannaki Sophia, Wang Wei, Hou Lifei, Okuno Toshiaki, Yuki Koichi
Department of Anesthesiology, Critical Care and Pain Medicine, Cardiac Anesthesia Division, Boston Children's Hospital, MA 02115, USA.
Department of Anaesthesia and Immunology, Harvard Medical School, Boston, MA 02115, USA.
Oncol Lett. 2024 Apr 30;27(6):287. doi: 10.3892/ol.2024.14420. eCollection 2024 Jun.
Use of volatile anesthetics is associated with worse outcome following tumor resection surgery compared with the use of intravenous anesthetics. However, the underlying mechanism has not been clearly delineated yet . The EO771 cell-based congenic breast cancer model was used in the present study. Isoflurane directly binds to and inhibits two adhesion molecules, leukocyte function-associated antigen-1 (LFA-1) and macrophage-1 antigen (Mac-1). Similarly, exposure to sevoflurane, another volatile anesthetic and LFA-1 inhibitor, is associated with an increase in breast cancer size compared with non-exposure. Thus, the present study first examined the role of LFA-1 and Mac-1 in the EO771 breast cancer model. Both LFA-1 deficiency and inhibition enhanced tumor growth, which was supported by cytokine and eicosanoid data profiles. By contrast, Mac-1 deficiency did not affect tumor growth. The exposure to isoflurane and sevoflurane was associated with an increase in breast cancer size compared with non-exposure. These data suggested that isoflurane enhanced tumor growth by interacting with LFA-1. Isoflurane exposure did not affect tumor growth in LFA-1-deficient mice. In summary, the present data showed that LFA-1 deficiency facilitated breast cancer growth, and isoflurane, an LFA-1 inhibitor, also increased breast cancer growth.
与使用静脉麻醉剂相比，挥发性麻醉剂的使用与肿瘤切除手术后更差的预后相关。然而，其潜在机制尚未明确。本研究使用了基于EO771细胞的同基因乳腺癌模型。异氟烷直接结合并抑制两种黏附分子，即白细胞功能相关抗原-1（LFA-1）和巨噬细胞-1抗原（Mac-1）。同样，与未接触相比，接触另一种挥发性麻醉剂和LFA-1抑制剂七氟烷与乳腺癌大小增加有关。因此，本研究首先在EO771乳腺癌模型中研究了LFA-1和Mac-1的作用。LFA-1缺乏和抑制均增强了肿瘤生长，细胞因子和类花生酸数据概况支持了这一点。相比之下，Mac-1缺乏并不影响肿瘤生长。与未接触相比，接触异氟烷和七氟烷与乳腺癌大小增加有关。这些数据表明，异氟烷通过与LFA-1相互作用增强了肿瘤生长。异氟烷暴露对LFA-1缺乏小鼠的肿瘤生长没有影响。总之，目前的数据表明，LFA-1缺乏促进了乳腺癌生长，而LFA-1抑制剂异氟烷也增加了乳腺癌生长。
