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全身麻醉药物选择在癌症转归中的作用。

The Role of General Anesthetic Drug Selection in Cancer Outcome.

机构信息

Department of Anesthesiology, Critical Care and Pain Medicine, Cardiac Anesthesia Division, Boston Children's Hospital, Boston, USA.

出版信息

Biomed Res Int. 2021 Oct 7;2021:2563093. doi: 10.1155/2021/2563093. eCollection 2021.

DOI:10.1155/2021/2563093
PMID:34660784
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8516539/
Abstract

Cancer remains to be the leading cause of death globally. Surgery is a mainstay treatment for solid tumors. Thus, it is critical to optimize perioperative care. Anesthesia is a requisite component for surgical tumor resection, and general anesthesia is given in the vast majority of tumor resection cases. Because anesthetics are growingly recognized as immunomodulators, it is critical to optimize anesthetic regimens for cancer surgery if the selection can affect outcomes. Here, we reviewed the role of volatile and intravenous anesthesia used for cancer surgery in cancer recurrence.

摘要

癌症仍然是全球主要的死亡原因。手术是治疗实体肿瘤的主要方法。因此,优化围手术期护理至关重要。麻醉是手术切除肿瘤的必要组成部分,在绝大多数肿瘤切除病例中都给予全身麻醉。由于麻醉剂越来越被认为是免疫调节剂,如果选择可以影响结果,那么为癌症手术优化麻醉方案至关重要。在这里,我们回顾了用于癌症手术的挥发性和静脉麻醉在癌症复发中的作用。

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1
The Role of General Anesthetic Drug Selection in Cancer Outcome.全身麻醉药物选择在癌症转归中的作用。
Biomed Res Int. 2021 Oct 7;2021:2563093. doi: 10.1155/2021/2563093. eCollection 2021.
2
Effects of surgery and anesthetic choice on immunosuppression and cancer recurrence.手术和麻醉选择对免疫抑制和癌症复发的影响。
J Transl Med. 2018 Jan 18;16(1):8. doi: 10.1186/s12967-018-1389-7.
3
Long-term consequences of anesthetic technique after cancer surgery.癌症手术后麻醉技术的长期后果。
Khirurgiia (Sofiia). 2014(2):69-74.
4
Anesthesia and cancer recurrences: The current knowledge and evidence.麻醉与癌症复发:当前的认识与证据。
J Cancer Res Ther. 2015 Jul-Sep;11(3):528-34. doi: 10.4103/0973-1482.157321.
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Cancer recurrence after surgery: direct and indirect effects of anesthetic agents.手术后癌症复发:麻醉剂的直接和间接影响。
Int J Cancer. 2012 Mar 15;130(6):1237-50. doi: 10.1002/ijc.26448. Epub 2011 Nov 9.
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Implicating anaesthesia and the perioperative period in cancer recurrence and metastasis.将麻醉和围手术期与癌症复发和转移联系起来。
Clin Exp Metastasis. 2018 Apr;35(4):347-358. doi: 10.1007/s10585-017-9862-x. Epub 2017 Sep 11.
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Anesthetic techniques and cancer recurrence after surgery.麻醉技术与术后癌症复发
ScientificWorldJournal. 2014 Feb 6;2014:328513. doi: 10.1155/2014/328513. eCollection 2014.
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Anesthetic technique and cancer recurrence in oncologic surgery: unraveling the puzzle.肿瘤手术中的麻醉技术与癌症复发:解开谜团
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Anesthetics impact on cancer recurrence: What do we know?麻醉剂对癌症复发的影响:我们了解什么?
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Effect of anaesthetic technique and other perioperative factors on cancer recurrence.麻醉技术及其他围手术期因素对癌症复发的影响。
Br J Anaesth. 2010 Aug;105(2):106-15. doi: 10.1093/bja/aeq164.

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Oncol Lett. 2024 Apr 30;27(6):287. doi: 10.3892/ol.2024.14420. eCollection 2024 Jun.
2
Tumor Necrosis Factor Alpha: Implications of Anesthesia on Cancers.肿瘤坏死因子α:麻醉对癌症的影响
Cancers (Basel). 2023 Jan 25;15(3):739. doi: 10.3390/cancers15030739.
3
Long-term oncological outcomes after oral cancer surgery using propofol-based total intravenous anesthesia versus sevoflurane-based inhalation anesthesia: A retrospective cohort study.口腔癌手术后使用依托咪酯全凭静脉麻醉与七氟醚吸入麻醉的长期肿瘤学结局:一项回顾性队列研究。
PLoS One. 2022 May 13;17(5):e0268473. doi: 10.1371/journal.pone.0268473. eCollection 2022.

本文引用的文献

1
Mechanistic consideration of the effect of perioperative volatile anesthetics on phagocytes.围手术期挥发性麻醉剂对吞噬细胞影响的作用机制研究。
Clin Immunol. 2021 Jan;222:108635. doi: 10.1016/j.clim.2020.108635. Epub 2020 Nov 17.
2
Perioperative and anesthetic risk factors of surgical site infection in patients undergoing pancreaticoduodenectomy: A retrospective cohort study.胰十二指肠切除术患者手术部位感染的围手术期和麻醉风险因素:一项回顾性队列研究。
PLoS One. 2020 Oct 14;15(10):e0240490. doi: 10.1371/journal.pone.0240490. eCollection 2020.
3
Volatile Anesthetic Sevoflurane Attenuates Toll-Like Receptor 1/2 Activation.挥发性麻醉剂七氟醚可减弱 Toll 样受体 1/2 的激活。
Anesth Analg. 2020 Aug;131(2):631-639. doi: 10.1213/ANE.0000000000004741.
4
Retrospective Comparison between the Effects of Propofol and Inhalation Anesthetics on Postoperative Recurrence of Early- and Intermediate-Stage Hepatocellular Carcinoma.异丙酚与吸入麻醉药对早期和中期肝细胞癌术后复发影响的回顾性比较。
Med Princ Pract. 2020;29(5):422-428. doi: 10.1159/000506637. Epub 2020 Feb 20.
5
Propofol-based total intravenous anesthesia is associated with better survival than desflurane anesthesia in intrahepatic cholangiocarcinoma surgery.在肝内胆管癌手术中,丙泊酚全静脉麻醉比地氟醚麻醉具有更好的生存率。
Medicine (Baltimore). 2019 Dec;98(51):e18472. doi: 10.1097/MD.0000000000018472.
6
The Effects Of Sevoflurane On The Progression And Cisplatinum Sensitivity Of Cervical Cancer Cells.七氟醚对宫颈癌细胞进展及顺铂敏感性的影响
Drug Des Devel Ther. 2019 Nov 18;13:3919-3928. doi: 10.2147/DDDT.S219788. eCollection 2019.
7
Propofol-based total intravenous anesthesia did not improve survival compared to desflurane anesthesia in breast cancer surgery.丙泊酚全静脉麻醉与地氟烷麻醉相比并未改善乳腺癌手术患者的生存率。
PLoS One. 2019 Nov 7;14(11):e0224728. doi: 10.1371/journal.pone.0224728. eCollection 2019.
8
Retrospective analysis of 1-year mortality after gastric cancer surgery: Total intravenous anesthesia versus volatile anesthesia.胃癌手术后 1 年死亡率的回顾性分析:全静脉麻醉与挥发性麻醉。
Acta Anaesthesiol Scand. 2019 Oct;63(9):1169-1177. doi: 10.1111/aas.13414. Epub 2019 Jun 10.
9
Propofol-based total intravenous anaesthesia is associated with better survival than desflurane anaesthesia in hepatectomy for hepatocellular carcinoma: a retrospective cohort study.丙泊酚全静脉麻醉与地氟烷麻醉在肝癌肝切除术中的生存关系:一项回顾性队列研究。
Br J Anaesth. 2019 Aug;123(2):151-160. doi: 10.1016/j.bja.2019.04.057. Epub 2019 Jun 3.
10
Volatile anesthetics affect macrophage phagocytosis.挥发性麻醉剂会影响巨噬细胞的吞噬作用。
PLoS One. 2019 May 9;14(5):e0216163. doi: 10.1371/journal.pone.0216163. eCollection 2019.