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在兰契RIMS医院就诊的急性髓系白血病患者中CD标志物的异常表达——一项观察性研究。

Aberrant expression of CD markers in AML in patients attending RIMS, Ranchi - An observational study.

作者信息

Ranjan Amit, Mahto Sunil K, Anand Nicky, Barla Nidhi P A

机构信息

Department of Pathology, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India.

出版信息

J Family Med Prim Care. 2024 Mar;13(3):841-844. doi: 10.4103/jfmpc.jfmpc_754_23. Epub 2024 Apr 4.

DOI:10.4103/jfmpc.jfmpc_754_23
PMID:38736799
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11086789/
Abstract

INTRODUCTION

Acute myeloid leukaemia (AML) is a tumour of hematopoietic progenitors caused by acquired oncogenic mutations that impede differentiation, leading to the accumulation of immature myeloid blasts in the marrow. Aberrant phenotype is a phenomenon in which lymphoid-associated and other myeloid lineage markers are expressed in myeloblasts or myeloid-associated markers are expressed in lymphoblasts.

MATERIALS AND METHODS

Diagnosed cases of AML were included in this study to study the aberrant expression using multiparametric flow cytometry.

RESULTS

Out of a sample size of 50, 30 cases expressed aberrant CD markers. Male: Female ratio was 0.76. Majority of cases belonged to the age group >60 years of age. CD 7 was overall the most common aberrant CD marker.

CONCLUSION

Immunophenotyping has a significant role in diagnosis and predicting prognosis of hematopoietic malignancies in the absence of more advanced diagnostic tools like cytogenetics.

摘要

引言

急性髓系白血病（AML）是一种造血祖细胞肿瘤，由获得性致癌突变引起，这些突变阻碍分化，导致骨髓中未成熟髓系母细胞积累。异常表型是指髓母细胞中表达淋巴样相关及其他髓系谱系标志物，或淋巴母细胞中表达髓系相关标志物的现象。

材料与方法

本研究纳入确诊的AML病例，采用多参数流式细胞术研究异常表达情况。

结果

在50例样本中，30例表达异常CD标志物。男女比例为0.76。大多数病例属于年龄>60岁的年龄组。CD7总体上是最常见的异常CD标志物。

结论

在缺乏细胞遗传学等更先进诊断工具的情况下，免疫表型分析在造血系统恶性肿瘤的诊断和预后预测中具有重要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34ab/11086789/cd6a7c18a3a2/JFMPC-13-841-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34ab/11086789/1ed41569d517/JFMPC-13-841-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34ab/11086789/4796d16e50fa/JFMPC-13-841-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34ab/11086789/ae986dd5a0f6/JFMPC-13-841-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34ab/11086789/ff907c195cb0/JFMPC-13-841-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34ab/11086789/49919f60d8c0/JFMPC-13-841-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34ab/11086789/cd6a7c18a3a2/JFMPC-13-841-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34ab/11086789/1ed41569d517/JFMPC-13-841-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34ab/11086789/4796d16e50fa/JFMPC-13-841-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34ab/11086789/ae986dd5a0f6/JFMPC-13-841-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34ab/11086789/ff907c195cb0/JFMPC-13-841-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34ab/11086789/49919f60d8c0/JFMPC-13-841-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34ab/11086789/cd6a7c18a3a2/JFMPC-13-841-g006.jpg

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Expression of aberrant CD markers in acute leukemia: a study of 100 cases with immunophenotyping by multiparameter flowcytometry.急性白血病中异常CD标志物的表达：100例多参数流式细胞术免疫表型分析研究
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