Dresdale A, Rose E A, Jeevanandam V, Reemtsma K, Bowman F O, Malm J R
Surgery. 1985 Jun;97(6):750-5.
Fibrin glue is used widely in Europe as a tissue sealant and hemostatic agent. The European glue is prepared commercially from pooled human blood. It is not available in this country because of the risk of transmission of hepatitis B, acquired immune deficiency syndrome, and other blood-transmitted diseases. We describe a cryoprecipitation technique for preparation of fibrin glue from single-donor fresh-frozen plasma. This technique enables the glue to be made in large quantities with no greater risk of disease transmission than with that from the transfusion of single-unit fresh-frozen plasma. We have found that the glue is a useful tool in surgery. By helping to control difficult bleeding, its use can decrease the need for blood transfusions and shorten operating room time. It also is effective as a means to pretreat highly porous vascular prostheses that currently are used infrequently because of bleeding. These porous grafts offer potential advantages in handling, suturing, and long-term patency. This new technique of fibrin glue preparation may make this useful surgical adjunct as readily available in this country as it is in Europe.
纤维蛋白胶在欧洲被广泛用作组织密封剂和止血剂。欧洲的这种胶水是用汇集的人血商业制备的。由于存在传播乙型肝炎、获得性免疫缺陷综合征及其他血液传播疾病的风险，该国无法获得这种胶水。我们描述了一种从单供体新鲜冰冻血浆制备纤维蛋白胶的冷沉淀技术。该技术能大量制备胶水，且疾病传播风险不比输注单单位新鲜冰冻血浆更高。我们发现这种胶水在手术中是一种有用的工具。通过帮助控制难治性出血，其使用可减少输血需求并缩短手术时间。它作为一种预处理目前因出血而很少使用的高度多孔血管假体的手段也很有效。这些多孔移植物在处理、缝合和长期通畅方面具有潜在优势。这种制备纤维蛋白胶的新技术可能使这种有用的手术辅助工具在该国像在欧洲一样容易获得。
