van der Zee C E, van Dam R H, Dwinger R H, Nieuwenhuijs J, Zwart D
Vet Immunol Immunopathol. 1985 Apr;8(4):341-50. doi: 10.1016/0165-2427(85)90004-2.
Goats infected with Trypanosoma brucei and treated with the non-steroidal anti-inflammatory agent flurbiprofen, showed a marked increase in parasitaemia, followed in one of the four goats by death. The in vitro response to mitogens of peripheral blood lymphocytes and separated T- and B-lymphocytes from healthy goats treated with flurbiprofen was normal when compared with non-treated animals. T. brucei-infected goats, not treated with flurbiprofen, showed a marked immunosuppression which was mainly localized in the B-enriched lymphocyte fraction. A combination of T. brucei infection and treatment with flurbiprofen led to even more suppression, because the T-lymphocyte function was also suppressed. It is concluded that flurbiprofen first causes a rise in the parasitaemia and that this high parasitaemia is responsible for the observed immunosuppression.
感染布氏锥虫并接受非甾体抗炎药氟比洛芬治疗的山羊，其寄生虫血症显著增加，四只山羊中有一只随后死亡。与未治疗的动物相比，用氟比洛芬治疗的健康山羊外周血淋巴细胞以及分离出的T淋巴细胞和B淋巴细胞对有丝分裂原的体外反应正常。未用氟比洛芬治疗的感染布氏锥虫的山羊表现出明显的免疫抑制，主要局限于富含B淋巴细胞的部分。布氏锥虫感染与氟比洛芬治疗相结合导致更严重的抑制，因为T淋巴细胞功能也受到抑制。结论是氟比洛芬首先导致寄生虫血症升高，而这种高寄生虫血症是观察到的免疫抑制的原因。
