Dwinger R H, Vos J, Nieuwenhuijs J, Zwart D, van Miert A S
J Vet Pharmacol Ther. 1984 Dec;7(4):293-301. doi: 10.1111/j.1365-2885.1984.tb00914.x.
The non-steroidal anti-inflammatory drug (NSAID) flurbiprofen caused a rise in parasitaemia in goats infected with Trypanosoma vivax, Trypanosoma congolense and Trypanosoma brucei. All trypanosome-infected goats treated with flurbiprofen showed many dividing trypanosomes. This also included the short-stumpy forms of T. brucei. In T. vivax-infected goats flurbiprofen treatment resulted in 100% mortality in the acute and chronic stages of the infection. The increase in parasitaemia of T. brucei infected goats, treated with flurbiprofen, was not associated with an increase in mortality. The increase in parasitaemia of T. congolense-infected goats, treated with flurbiprofen, tended to be associated with a somewhat higher mortality but this was statistically not significant. The significant rise in parasitaemia could be reproduced in T. brucei-infected sheep without, however, killing the animals. Two other NSAIDs were also studied. Suprofen caused a rise in parasitaemia and 100% mortality when given to goats in the acute stage of T. vivax infection. Results with flunixin meglumine, when tested in T. brucei infected goats, were not conclusive.
非甾体抗炎药氟比洛芬可使感染活跃锥虫、刚果锥虫和布氏锥虫的山羊体内寄生虫血症升高。所有接受氟比洛芬治疗的感染锥虫的山羊体内都出现了许多正在分裂的锥虫。这其中还包括布氏锥虫的短粗型。在感染活跃锥虫的山羊中，氟比洛芬治疗在感染的急性期和慢性期导致100%的死亡率。用氟比洛芬治疗的感染布氏锥虫的山羊，其寄生虫血症的增加与死亡率的增加无关。用氟比洛芬治疗的感染刚果锥虫的山羊，其寄生虫血症的增加往往与略高的死亡率相关，但在统计学上并不显著。感染布氏锥虫的绵羊中也可重现寄生虫血症的显著升高，不过，这些绵羊并未死亡。还研究了另外两种非甾体抗炎药。舒洛芬在活跃锥虫感染急性期给予山羊时，会导致寄生虫血症升高和100%的死亡率。在感染布氏锥虫的山羊中测试氟尼辛葡甲胺时，结果尚无定论。
