Zwart D, Brun R, Dwinger R H, van Miert A S, Franssen F F, Nieuwenhuijs J, Kooy R F
Department of Tropical Veterinary Medicine and Protozoology, University of Utrecht, The Netherlands.
Acta Trop. 1990 Feb;47(2):115-23. doi: 10.1016/0001-706x(90)90073-9.
The administration of flurbiprofen, a potent non-steroidal anti-inflammatory drug (NSAID), to goats infected with trypanosomes resulted in high elevated parasitaemia and suppression of fever. In contrast to goats, rats infected with trypanosomes do not show febrile reactions. Therefore, the role of body temperature was investigated with yeast-induced fever in Trypanosoma evansi and T. brucei infected rats. These investigations did not support the hypothesis that a high body temperature causes a drop in parasitaemia. In goats infected with trypanosomes, it is also unlikely that fever has an inhibitory influence on the parasitaemia. In these animals, rises in parasitaemia could be provoked by doses of flurbiprofen as low as 1/20 of the normal doses and these doses did not or only partly suppressed fever. No effect on parasite growth could be obtained when flurbiprofen was added in concentrations up to 32 micrograms/ml directly to T. brucei cultures. Moreover, no growth promoting factor(s) could be identified in vitro in serum from flurbiprofen-treated goats.
给感染锥虫的山羊施用强效非甾体抗炎药（NSAID）氟比洛芬，会导致寄生虫血症大幅升高并抑制发热。与山羊不同，感染锥虫的大鼠不会出现发热反应。因此，利用酵母诱导的发热，在感染伊氏锥虫和布氏锥虫的大鼠中研究了体温的作用。这些研究并不支持体温升高会导致寄生虫血症下降这一假说。在感染锥虫的山羊中，发热对寄生虫血症也不太可能有抑制作用。在这些动物中，低至正常剂量1/20的氟比洛芬就能引发寄生虫血症升高，而且这些剂量并未或仅部分抑制发热。将浓度高达32微克/毫升的氟比洛芬直接添加到布氏锥虫培养物中，对寄生虫生长没有影响。此外，在氟比洛芬处理过的山羊血清中，体外未鉴定出促生长因子。
