Karatabanova N A, Spirichev V B, Sokolova S V, Bogoslovskiĭ N A
Vopr Pitan. 1985 Mar-Apr(2):52-6.
High content of phosphorus in the diet (1.8% of phosphorus in the diet, Ca:P ratio 1:3) accelerated the development of hypocalcemia and osteoporosis and increased their degree in rats which received hydrocortisone (3.5 mg/10 g bw a day for 4 weeks). Reduction of phosphorus consumption to 0.3% (Ca:P ration 1:0.5) essentially retarded the development of these disturbances and lowered their degree. The use of 1,25-dioxycholecalciferol and 24,25-dioxycholecalciferol in doses of 0.03 and 1.5 mg, respectively promoted the normalization of phosphorus-calcium metabolism and improvement of the status of the osseous tissue in rats given hydrocortisone coupled with both diets. The most beneficial affect on calcium homeostasis in exogenous hypercorticoidism was attained with the use of active metabolites of vitamin D3 coupled with the diet with a low phosphorus content (0.3%). In this case there was a complete normalization of the density of the osseous tissue and of the calcium and phosphorus content. In view of this fact it is advisable to combine active metabolites of vitamin D3 and the diet with a low phosphorus content.
饮食中高磷含量（饮食中磷含量为1.8%，钙磷比为1:3）加速了低钙血症和骨质疏松症的发展，并加重了接受氢化可的松（3.5毫克/10克体重，每日一次，共4周）的大鼠的这些病症程度。将磷摄入量降至0.3%（钙磷比为1:0.5）基本上延缓了这些病症的发展并减轻了其程度。分别以0.03毫克和1.5毫克的剂量使用1,25-二羟胆钙化醇和24,25-二羟胆钙化醇，可促进接受氢化可的松且食用这两种饮食的大鼠的磷钙代谢正常化，并改善骨组织状况。使用维生素D3的活性代谢物并搭配低磷含量（0.3%）的饮食，对外源性皮质醇增多症的钙稳态产生了最有益的影响。在这种情况下，骨组织密度以及钙和磷含量完全恢复正常。鉴于这一事实，建议将维生素D3的活性代谢物与低磷含量的饮食相结合。
