Ushakov A S, Spirichev V B, Sergeev I N, Belakovsky M S, Blazhejevich N V, Bogoslovsky N A
Aviat Space Environ Med. 1983 May;54(5):447-51.
Severe hypokinesia of rats given the diet with a ratio of Ca:P = 1:0.5-1:3 was accompanied by hypocalcemia, development of osteoporosis, and some intensification of renal calcinosis. The decrease of phosphorus consumption (Ca:P = 1:0.5-1:1) prevented a development of these changes in intact animals and increased bone mineralization in hypokinetic ones. Excessive phosphorus consumption (Ca:P = 1:3) produced hypocalcemia, hyperphosphatemia, and some osteoporotic changes in the bones of intact animals and intensified these changes with hypokinesia. Administration of 24,25-dihydroxycholecalciferol, an active metabolite of vitamin D3, at a dose of 1.25 micrograms/d prevented a development of bone disorders, thus effectively stimulating diaphyses and epiphyses mineralization and correcting hypocalcemia in hypokinetic rats. 24,25(OH)2D3 at the same dose did not intensify nephocalcinosis and produced no toxic symptoms with hypokinetic animals.
给大鼠喂食钙磷比为1:0.5至1:3的饮食时，严重运动功能减退伴有低钙血症、骨质疏松症的发展以及肾钙质沉着症的一些加重。磷摄入量减少（钙磷比为1:0.5至1:1）可防止完整动物出现这些变化，并增加运动功能减退动物的骨矿化。磷摄入过多（钙磷比为1:3）会导致完整动物出现低钙血症、高磷血症和骨骼中的一些骨质疏松变化，并在运动功能减退时加剧这些变化。以1.25微克/天的剂量给予维生素D3的活性代谢物24,25-二羟基胆钙化醇，可防止骨骼疾病的发展，从而有效刺激骨干和骨骺矿化，并纠正运动功能减退大鼠的低钙血症。相同剂量的24,25(OH)2D3不会加重肾钙质沉着症，且对运动功能减退的动物未产生毒性症状。
