Xiao Hui-Ni, Zhao Zi-Yue, Li Jin-Ping, Li Ao-Yu
Department of Gastroenterology, the Second Affiliated Hospital, University of South China, Hengyang, China.
Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, China.
Transl Cancer Res. 2024 Apr 30;13(4):1642-1664. doi: 10.21037/tcr-23-2050. Epub 2024 Apr 19.
The adenosine triphosphate-binding-cassette (ABC) transporter orchestrates the transmembrane transport of diverse substrates with the aid of ATP as an energy source. ABC transporter constitutes a widespread superfamily of transporters prominently present on the cellular membrane of organisms. Advancements in understanding have unveiled additional roles beyond mere intracellular or extracellular transport functions for the ABC protein family, encompassing involvement in DNA repair, protein translation, and gene expression regulation. Yet its role in tumors is still unknown.
This study drew support from multiple databases, including Gene Expression Omnibus (GEO), European Genome-phenome Archive (EGA), The Cancer Genome Atlas (TCGA), and employed multidimensional bioinformatics analyses, incorporating online databases and the R-project. Through a comprehensive analysis, we seek to discern transcriptional-level disparities among genes and their consequential impacts on prognosis, tumor microenvironment (TME), stemness score, immune subtypes, clinical characteristics, and drug sensitivity across human cancers.
ABC transporter subfamily B (ABCB) family genes exhibited heightened expression across diverse tumors, demonstrating a significant correlation with overall prognosis in pan-cancer contexts. Notably, gene expression levels manifested substantial associations with TME, stemness score, immune subtypes, clinical characteristics, and drug sensitivity in specific cancers, including kidney renal papillary cell carcinoma (KIRP), liver hepatocellular carcinoma (LIHC), and pancreatic adenocarcinoma (PAAD). Within this subset, transporter associated with antigen processing 1 (), , and emerged as noteworthy oncogenes.
The outcomes of this study contribute to a comprehensive understanding of the implications of ABCB family genes in tumor progression, offering insights into potential therapeutic targets for cancer. Notably, the identification of as a significant oncogene suggests promising avenues for targeted therapies in KIRP, LIHC, and PAAD.
三磷酸腺苷结合盒（ABC）转运蛋白借助ATP作为能量来源，协调多种底物的跨膜运输。ABC转运蛋白构成了一个广泛存在的转运蛋白超家族，在生物体的细胞膜上显著存在。对其认识的进展揭示了ABC蛋白家族除了单纯的细胞内或细胞外运输功能之外的其他作用，包括参与DNA修复、蛋白质翻译和基因表达调控。然而，其在肿瘤中的作用仍不清楚。
本研究得到了多个数据库的支持，包括基因表达综合数据库（GEO）、欧洲基因组-表型档案库（EGA）、癌症基因组图谱（TCGA），并采用了多维生物信息学分析，纳入了在线数据库和R项目。通过全面分析，我们试图辨别基因之间转录水平的差异及其对人类癌症的预后、肿瘤微环境（TME）、干性评分、免疫亚型、临床特征和药物敏感性的相应影响。
ABC转运蛋白亚家族B（ABCB）家族基因在多种肿瘤中表现出高表达，在泛癌背景下与总体预后显著相关。值得注意的是，基因表达水平在特定癌症中，包括肾肾乳头状细胞癌（KIRP）、肝细胞肝癌（LIHC）和胰腺腺癌（PAAD），与TME、干性评分、免疫亚型、临床特征和药物敏感性表现出显著关联。在这个子集中，抗原加工相关转运蛋白1（）、和成为值得注意的癌基因。
本研究结果有助于全面了解ABCB家族基因在肿瘤进展中的意义，为癌症潜在治疗靶点提供见解。值得注意的是，作为一个重要癌基因的鉴定为KIRP、LIHC和PAAD的靶向治疗提供了有前景的途径。
