Department of Neurology, China-Japan Union Hospital, Jilin University, Changchun, 130021, P. R. China.
Institute for Nutrition and Food Safety, Changchun Center for Disease Control and Prevention, Changchun, 130033, P. R. China.
Food Funct. 2024 Jun 4;15(11):5929-5941. doi: 10.1039/d3fo04675c.
: Chronic obstructive pulmonary disease (COPD) is a common respiratory disease, and its development and prognosis are influenced by many nutrients. However, the relationship between polyunsaturated fatty acids (PUFAs) and COPD remains unclear. : This study searched all literature reports on PUFAs and COPD based on electronic databases from their inception up to October 2023. Meta-analysis was conducted to evaluate the differences in PUFAs between COPD patients and controls, the risk of COPD in subjects with different levels of PUFA concentrations, and the effect of PUFA supplementation on COPD. : A total of nineteen studies met our inclusion criteria, which included 155 636 subjects. Our meta-analysis results showed that the daily dietary intake of PUFAs was lower in COPD patients than in controls (SMD = -0.80 g, 95% CI: -1.28, -0.31 g, = 98.6%, < 0.001). Meanwhile, the lower n-3 PUFA levels and higher n-6 PUFA levels were associated with an increased risk of COPD (effect size n-3 = 0.87, 95% CI: 0.77, 0.98, = 52.2%, = 0.018; effect size n-6 = 1.23, 95% CI: 1.05, 1.43, = 75.2%, < 0.001). Furthermore, the content of low-density lipoprotein cholesterol in the PUFA supplementation group was higher than that in the control group (SMD = 0.63 mg dL, 95% CI: 0.15, 1.12 mg dL, = 0.0%, = 0.697). : Our meta-analysis indicated a potential relationship between PUFAs and COPD. More large-scale prospective cohort studies and clinical trials are necessary to validate this relationship.
慢性阻塞性肺疾病（COPD）是一种常见的呼吸道疾病，其发生和预后受到许多营养素的影响。然而，多不饱和脂肪酸（PUFAs）与 COPD 之间的关系尚不清楚。
本研究基于电子数据库，从建库至 2023 年 10 月，全面检索了关于 PUFAs 和 COPD 的所有文献报告。采用荟萃分析评估了 COPD 患者和对照组之间 PUFAs 的差异、不同 PUFA 浓度受试者患 COPD 的风险，以及 PUFAs 补充对 COPD 的影响。
共有 19 项研究符合纳入标准，共纳入 155636 例受试者。我们的荟萃分析结果表明，COPD 患者的 PUFAs 日膳食摄入量低于对照组（SMD=-0.80g，95%CI：-1.28，-0.31g， =98.6%， <0.001）。此外，n-3PUFA 水平较低和 n-6PUFA 水平较高与 COPD 风险增加相关（n-3 效应大小=0.87，95%CI：0.77，0.98， =52.2%， =0.018；n-6 效应大小=1.23，95%CI：1.05，1.43， =75.2%， <0.001）。而且，PUFA 补充组的低密度脂蛋白胆固醇含量高于对照组（SMD=0.63mgdL，95%CI：0.15，1.12mgdL， =0.0%， =0.697）。
本荟萃分析表明 PUFAs 与 COPD 之间可能存在关联。需要更多大规模的前瞻性队列研究和临床试验来验证这种关系。
