College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 102488, China.
J Ethnopharmacol. 2024 Oct 5;332:118325. doi: 10.1016/j.jep.2024.118325. Epub 2024 May 11.
Celosia cristata L. (C. cristata) is a widely used herb in China and has been used as a medicine for more than 1000 years. The herb has been clinically employed to treat various types of bleeding disorders including metrorrhagia, metrostaxis, and leukorrheal diseases, gastrointestinal infections.
This review provides a comprehensive analysis of C. cristata, encompassing its botany, traditional applications, phytochemistry, pharmacology, safety, and quality control. Additionally, it delves into the prevailing challenges and limitations with contemporary research concerning C. cristata, thus furnishing valuable insights for future investigations in this domain.
Research data were gathered from authoritative sources including the Pharmacopoeia of China, the Flora of China, as well as various internet databases such as Web of Science, CAS CiFinder, PubMed, Science Direct, and CNKI, along with numerous ancient classics on Chinese herbal medicine.
Clinical applications of C. cristata demonstrate its efficacy in treating dysfunctional uterine bleeding, vaginitis, and pelvic inflammatory disease. Presently, seventy-seven compounds have been isolated, including flavonoids, triterpenoids, steroids, organic acids, phenylpropanoids, and alkaloids, with flavonoids and triterpenoids emerging as the primary bioactive constituents. Pharmacological studies reveal its diverse biological activities, such as haemostatic, antitrichomonal, antibacterial, antiviral, analgesic, immunoregulatory, anti-inflammatory, anticancer, hepatoprotective, and antioxidant effects. Leveraging network pharmacology, researchers have embarked on preliminary inquiries into the interplay among chemical constituents, molecular targets and pathological conditions.
C. cristata shows significant potential for use in hemostasis, anti-inflammatory, and antimicrobial treatments. Modern research has revealed its diverse chemical composition and pharmacological activities, making it highly valuable for further study. At the same time, it is necessary to find the characteristic components of C. cristata and establish better quality control standards to better explore its therapeutic potential.
鸡冠花（C. cristata）在中国被广泛用作草药，已有 1000 多年的药用历史。该草药已在临床上用于治疗各种出血性疾病，包括月经过多、经行先期、带下病、胃肠道感染。
本综述全面分析了鸡冠花，涵盖其植物学、传统应用、植物化学、药理学、安全性和质量控制。此外，还深入探讨了当代鸡冠花研究中存在的挑战和局限性，为该领域的未来研究提供了有价值的见解。
研究数据来自权威来源，包括《中国药典》、《中国植物志》以及 Web of Science、CAS CiFinder、PubMed、Science Direct 和中国知网等多个互联网数据库，以及大量中草药古籍。
鸡冠花的临床应用表明其在治疗功能性子宫出血、阴道炎和盆腔炎方面的疗效。目前已分离得到 77 种化合物，包括黄酮类、三萜类、甾体类、有机酸类、苯丙素类和生物碱类，其中黄酮类和三萜类是主要的生物活性成分。药理研究表明其具有多种生物活性，如止血、抗滴虫、抗菌、抗病毒、镇痛、免疫调节、抗炎、抗癌、保肝和抗氧化作用。利用网络药理学，研究人员初步探讨了化学成分、分子靶标和病理状况之间的相互作用。
鸡冠花在止血、抗炎和抗菌治疗方面显示出巨大的应用潜力。现代研究揭示了其多样的化学成分和药理学活性，使其具有很高的研究价值。同时，有必要找到鸡冠花的特征成分，建立更好的质量控制标准，以更好地挖掘其治疗潜力。
