Nutrition and Dietetics Research Group, Imperial College London, London, United Kingdom; UK Dementia Research Institute and Department of Brain Sciences, Imperial College London, London, United Kingdom.
Nutrition and Dietetics Research Group, Imperial College London, London, United Kingdom.
J Nutr. 2024 Aug;154(8):2470-2480. doi: 10.1016/j.tjnut.2024.05.005. Epub 2024 May 11.
Evidence suggests a link between polyphenol intake and reduced incidence of several chronic diseases. This could arise through associations between polyphenol intake and reduced systemic oxidative stress and subsequent inflammation. However, confirming this association is difficult, as few large cohorts allow for comprehensive assessments of both polyphenol intake and markers of systemic inflammation.
To address this, polyphenol intake was assessed in the UK-based Airwave cohort using 7-d diet diaries and data from Phenol-Explorer to test for associations between polyphenol intake and blood biomarkers of inflammation.
Participants included 9008 males and females aged 17-74 y (median age: 42 y) whose data was included in a cross-sectional analysis. Phenol-Explorer was used to estimate individuals' polyphenol intake from diet data describing the consumption of 4104 unique food items. C-reactive protein (CRP) and fibrinogen were used as blood biomarkers of inflammation.
There were 448 polyphenols found in reported diet items. Median total polyphenol intake was 1536 mg/d (1058-2092 mg/d). Phenolic acids and flavonoids were the main types of polyphenols, and nonalcoholic beverages, vegetables, and fruit were the primary sources. Variation in energy-adjusted polyphenol intake was explained by age, sex, salary, body mass index, education level, smoking, and alcohol consumption. Linear regressions showed inverse associations between total daily intake and both CRP (β: -0.00702; P < 0.001) and fibrinogen (β: -0.00221; P = 0.038). Associations with specific polyphenol compound groups were also found. Logistic regressions using total polyphenol intake quartiles showed stepwise reductions in the odds of elevated CRP with higher intake (6%, 23%, and 24% compared with quartile 1; P = 0.003), alongside 3% and 7% lower odds per unit of polyphenol consumption equivalent to 1 cup of tea or coffee per day.
This study describes polyphenol intake in a large, contemporary UK cohort. We observed associations between higher intake and lower CRP and fibrinogen. This contributes to evidence supporting the health benefits of dietary polyphenols.
有证据表明，多酚摄入量与多种慢性疾病发病率降低之间存在关联。这种关联可能是由于多酚摄入量与全身氧化应激和随后的炎症减轻之间存在关联。然而，要证实这种关联具有一定难度，因为很少有大型队列研究能够全面评估多酚摄入量和全身炎症标志物。
为了解决这一问题，我们使用英国 Airwave 队列中的 7 天饮食日记评估多酚摄入量，并使用 Phenol-Explorer 评估多酚摄入量与炎症血液生物标志物之间的关系。
参与者包括 9008 名年龄在 17-74 岁（平均年龄：42 岁）的男性和女性，其数据纳入了一项横断面分析。使用 Phenol-Explorer 根据描述 4104 种独特食物消费的饮食数据估计个体的多酚摄入量。C 反应蛋白（CRP）和纤维蛋白原被用作炎症的血液生物标志物。
报告的饮食项目中发现了 448 种多酚。中位数总多酚摄入量为 1536mg/d（1058-2092mg/d）。类黄酮酸和类黄酮是主要的多酚类型，非酒精性饮料、蔬菜和水果是主要来源。经能量调整后的多酚摄入量的差异可由年龄、性别、工资、体重指数、教育程度、吸烟和饮酒来解释。线性回归显示，总日摄入量与 CRP（β：-0.00702；P<0.001）和纤维蛋白原（β：-0.00221；P=0.038）呈负相关。还发现了与特定多酚化合物组的关联。使用总多酚摄入量四分位数的逻辑回归显示，随着摄入量的增加，CRP 升高的几率呈逐步下降趋势（与四分位 1 相比，6%、23%和 24%；P=0.003），与每天饮用 1 杯茶或咖啡相当的多酚消耗量每增加 1 个单位，几率分别降低 3%和 7%。
本研究描述了一个大型的当代英国队列中的多酚摄入量。我们观察到较高的摄入量与 CRP 和纤维蛋白原降低之间存在关联。这为支持饮食多酚对健康有益的证据做出了贡献。
