Verhaeghe R, Verstraete M, Schetz J, Vanhove P, Suy R, Vermylen J
Eur J Clin Pharmacol. 1979 Sep;16(3):165-70. doi: 10.1007/BF00562056.
A randomized, single-blind trial of repeated intravenous infusion of Brinase was carried out in 70 petients with severe chronic limb ischemia, who were candidates for lumbar sympathectomy or amputation. The enzyme caused s significant increase in calf and ankle pressure index. At six months follow-up, the clinical results were statistically significant in favour of Brinase when all patients were considered, but not if 10 patients with Buerger's disease were omitted from the analysis. Patients treated with a combination of Brinase and coumarins had a better clinical outcome than patients receiving either treatment on its own.
对70例严重慢性肢体缺血患者进行了一项重复静脉输注布立酶的随机单盲试验，这些患者均为腰交感神经切除术或截肢手术的候选者。该酶使小腿和踝关节压力指数显著升高。在六个月的随访中，当将所有患者纳入考虑时，临床结果在统计学上显著有利于布立酶，但如果分析中排除10例伯格氏病患者，则并非如此。联合使用布立酶和香豆素治疗的患者比单独接受任何一种治疗的患者临床结局更好。
