FitzGerald D E, Frisch E P, Milliken J C
Scand J Thorac Cardiovasc Surg. 1979;13(3):327-32. doi: 10.3109/14017437909100573.
A therapeutic trial using placebo or the thrombolytic enzyme brinase was carried out in a group of patients with chronic arterial obstruction. The patients were observed for 3 months before receiving six intravenous infusions of either saline or brinase over a period of 2 weeks. Ankle blood pressure, Doppler ultrasound scanning, and arteriography were used to establish diagnosis in the patients. No changes were observed during the 3-month pre-observation period. After six brinase infusions, recanalization of 17 out of 27 obstructed arterial segments was recorded and the number of patent segments increased from 11 to 27. No improvement was observed in the placebo-treated patients. The differences between brinase and placebo treatment was statistically significant.
在一组慢性动脉阻塞患者中进行了一项使用安慰剂或溶栓酶纤维蛋白溶酶的治疗试验。在接受为期2周的6次生理盐水或纤维蛋白溶酶静脉输注之前，对患者进行了3个月的观察。使用踝部血压、多普勒超声扫描和动脉造影对患者进行诊断。在3个月的观察前期未观察到变化。在6次纤维蛋白溶酶输注后，记录到27个阻塞动脉段中的17个再通，通畅段的数量从11个增加到27个。在接受安慰剂治疗的患者中未观察到改善。纤维蛋白溶酶治疗和安慰剂治疗之间的差异具有统计学意义。
