Tournebize Corentin, Lemoine Sandrine, Pelletier Caroline
Hospices civils de Lyon, Hôpital Edouard Herriot, service de néphrologie, dialyse et HTA, 69003 Lyon, France
Nephrol Ther. 2024 May 15;20(2):131-139. doi: 10.1684/ndt.2024.70. Epub 2024 Apr 4.
Fibromuscular dysplasia (FMD) is a rare nonatherosclerotic, noninflammatory vascular disease affecting mostly renal and carotid arteries and is the second most frequent cause of renal artery stenosis. The symptomatology is dominated by arterial hypertension due to the frequent involvement of the renal arteries and depends on the location of the lesions. Most of the cases are middle-aged women of Caucasian origin. There are two subtypes based on angiographic aspect: multifocal FMD (80% of the cases) and focal FMD (rarer with a more balanced sex ratio). Angioplasty of the renal arteries is generally disappointing with less than 50% cure of hypertension. It appears necessary to improve our knowledge of the FMD and to optimize the selection of eligible patients for revascularization with transdisciplinary collegial therapeutic decision.
纤维肌性发育异常（FMD）是一种罕见的非动脉粥样硬化、非炎症性血管疾病，主要影响肾动脉和颈动脉，是肾动脉狭窄的第二大常见病因。由于肾动脉频繁受累，症状以动脉高血压为主，且取决于病变部位。大多数病例为白种人中的中年女性。根据血管造影表现可分为两种亚型：多灶性FMD（占病例的80%）和局灶性FMD（较罕见，性别比例更均衡）。肾动脉血管成形术通常效果不佳，高血压治愈率不到50%。似乎有必要提高我们对FMD的认识，并通过跨学科的共同治疗决策优化血管重建合格患者的选择。
