磁共振弹性成像测量刚度的精度和测试-再测试重复性：一项多中心 phantom 研究。
Precision and Test-Retest Repeatability of Stiffness Measurement with MR Elastography: A Multicenter Phantom Study.
机构信息
From the BioMedical Engineering and Imaging Institute (E.O., P.K., O.B., B.T.) and Departments of Diagnostic, Molecular and Interventional Radiology (E.O., P.K., O.B., B.T.) Environmental Medicine and Public Health (J.T.D.), Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, New York, NY 10029; Department of Radiology, Mayo Clinic, Rochester, Minn (J.C., P.J.R., S.K.V., R.L.E.); Department of Radiology, Nanjing University Medical School Affiliated Drum Tower Hospital, Nanjing, China (J.C.); Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio (J.R.D., J.A.T.); Joint Department of Medical Imaging, University Health Network, Mount Sinai Hospital, and Women's College Hospital, University of Toronto, Toronto, Canada (K.S.J.); Department of Radiology and Biomedical Imaging, University of California, San Francisco, Calif (M.A.O.); and Department of Radiology, Zuckerberg San Francisco General Hospital, San Francisco, Calif (M.A.O.).
出版信息
Radiology. 2024 May;311(2):e233136. doi: 10.1148/radiol.233136.
Background MR elastography (MRE) has been shown to have excellent performance for noninvasive liver fibrosis staging. However, there is limited knowledge regarding the precision and test-retest repeatability of stiffness measurement with MRE in the multicenter setting. Purpose To determine the precision and test-retest repeatability of stiffness measurement with MRE across multiple centers using the same phantoms. Materials and Methods In this study, three cylindrical phantoms made of polyvinyl chloride gel mimicking different degrees of liver stiffness in humans (phantoms 1-3: soft, medium, and hard stiffness, respectively) were evaluated. Between January 2021 and January 2022, phantoms were circulated between five different centers and scanned with 10 MRE-equipped clinical 1.5-T and 3-T systems from three major vendors, using two-dimensional (2D) gradient-recalled echo (GRE) imaging and/or 2D spin-echo (SE) echo-planar imaging (EPI). Similar MRE acquisition parameters, hardware, and reconstruction algorithms were used at each center. Mean stiffness was measured by a single observer for each phantom and acquisition on a single section. Stiffness measurement precision and same-session test-retest repeatability were assessed using the coefficient of variation (CV) and the repeatability coefficient (RC), respectively. Results The mean precision represented by the CV was 5.8% (95% CI: 3.8, 7.7) for all phantoms and both sequences combined. For all phantoms, 2D GRE achieved a CV of 4.5% (95% CI: 3.3, 5.7) whereas 2D SE EPI achieved a CV of 7.8% (95% CI: 3.1, 12.6). The mean RC of stiffness measurement was 5.8% (95% CI: 3.7, 7.8) for all phantoms and both sequences combined, 4.9% (95% CI: 2.7, 7.0) for 2D GRE, and 7.0% (95% CI: 2.9, 11.2) for 2D SE EPI (all phantoms). Conclusion MRE had excellent in vitro precision and same-session test-retest repeatability in the multicenter setting when similar imaging protocols, hardware, and reconstruction algorithms were used. © RSNA, 2024 See also the editorial by Tang in this issue.
背景 磁共振弹性成像（MRE）已被证明在无创性肝纤维化分期方面具有出色的性能。然而，在多中心环境中，使用 MRE 进行弹性测量的精密度和测试-重测重复性的相关知识有限。目的 本研究旨在使用相同的体模确定 MRE 在多个中心进行的弹性测量的精密度和测试-重测重复性。材料与方法 本研究中，评估了三个由聚氯乙烯凝胶制成的圆柱形体模，分别模拟人类不同程度的肝硬度（体模 1-3：软、中、硬硬度）。在 2021 年 1 月至 2022 年 1 月期间，体模在五个不同的中心之间循环，并使用来自三个主要供应商的 10 台配备有二维（2D）梯度回波（GRE）成像和/或 2D 自旋回波（SE）EPI 的临床 1.5-T 和 3-T MRE 系统进行扫描。每个中心均使用相似的 MRE 采集参数、硬件和重建算法。由一名观察者在每个体模的单个节段上进行单次测量，以测量平均硬度。使用变异系数（CV）和重复性系数（RC）分别评估硬度测量的精密度和同一次测试-重测的重复性。结果 所有体模和两种序列组合的平均精度代表值（以 CV 表示）为 5.8%（95%CI：3.8，7.7）。对于所有体模，2D GRE 的 CV 为 4.5%（95%CI：3.3，5.7），而 2D SE EPI 的 CV 为 7.8%（95%CI：3.1，12.6）。所有体模和两种序列组合的平均 RC 为 5.8%（95%CI：3.7，7.8），2D GRE 的 RC 为 4.9%（95%CI：2.7，7.0），2D SE EPI 的 RC 为 7.0%（95%CI：2.9，11.2）。结论 在使用相似的成像方案、硬件和重建算法时，MRE 在多中心环境中具有出色的体外精密度和同一次测试-重测重复性。
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