Syn3是一种新开发的环肽和脑源性神经营养因子（BDNF）信号增强剂，可改善糖尿病视网膜病变中的视网膜神经节细胞变性。 - Suppr

Syn3, a newly developed cyclic peptide and BDNF signaling enhancer, ameliorates retinal ganglion cell degeneration in diabetic retinopathy.

作者信息

Li Ke-Ran, Huan Meng-Jia, Yao Jin, Li Jia-Jun, Cao Yuan, Wang Suyu, Naik Mandar T, Fang Yuan, Marshall John, Lan Chang-Gong, Cao Cong

机构信息

The Affiliated Eye Hospital, Nanjing Medical University, Nanjing 210029, China.

Department of Ophthalmology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

出版信息

Protein Cell. 2024 Nov 1;15(11):858-865. doi: 10.1093/procel/pwae028.

DOI:10.1093/procel/pwae028

PMID:38743493

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11528515/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1949/11528515/7a5303a70c32/pwae028_fig1.jpg

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Ophthalmic Res. 2021;64(3):345-355. doi: 10.1159/000514441. Epub 2021 Jan 15.

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Retina. 2020 Jan;40(1):121-125. doi: 10.1097/IAE.0000000000002355.

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Syn3, a newly developed cyclic peptide and BDNF signaling enhancer, ameliorates retinal ganglion cell degeneration in diabetic retinopathy.

作者信息

Li Ke-Ran, Huan Meng-Jia, Yao Jin, Li Jia-Jun, Cao Yuan, Wang Suyu, Naik Mandar T, Fang Yuan, Marshall John, Lan Chang-Gong, Cao Cong

机构信息

The Affiliated Eye Hospital, Nanjing Medical University, Nanjing 210029, China.

Department of Ophthalmology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

出版信息

Protein Cell. 2024 Nov 1;15(11):858-865. doi: 10.1093/procel/pwae028.

DOI:10.1093/procel/pwae028

PMID:38743493

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11528515/

Abstract

摘要

相似文献

Syn3, a newly developed cyclic peptide and BDNF signaling enhancer, ameliorates retinal ganglion cell degeneration in diabetic retinopathy.

Protein Cell. 2024 Nov 1;15(11):858-865. doi: 10.1093/procel/pwae028.

Topical administration of GLP-1 eyedrops improves retinal ganglion cell function by facilitating presynaptic GABA release in early experimental diabetes.

Neural Regen Res. 2026 Feb 1;21(2):800-810. doi: 10.4103/NRR.NRR-D-24-00001. Epub 2024 Jun 26.

Degeneration of retinal ganglion cells in diabetic dogs and mice: relationship to glycemic control and retinal capillary degeneration.

Mol Vis. 2013 Jun 27;19:1413-21. Print 2013.

Association between retinal neuronal degeneration and visual function impairment in type 2 diabetic patients without diabetic retinopathy.

Sci China Life Sci. 2015 Jun;58(6):550-5. doi: 10.1007/s11427-015-4858-8. Epub 2015 May 8.

Neuroprotective effect of He-Ying-Qing-Re formula on retinal ganglion cell in diabetic retinopathy.

J Ethnopharmacol. 2018 Mar 25;214:179-189. doi: 10.1016/j.jep.2017.12.018. Epub 2017 Dec 15.

Extracellular Mitochondria Exacerbate Retinal Pigment Epithelium Degeneration in Diabetic Retinopathy.

Diabetes. 2025 Mar 1;74(3):409-415. doi: 10.2337/db24-0040.

Overexpression of D-amino acid oxidase prevents retinal neurovascular pathologies in diabetic rats.

Diabetologia. 2021 Mar;64(3):693-706. doi: 10.1007/s00125-020-05333-y. Epub 2020 Dec 14.

Antagonising Wnt/β-catenin signalling ameliorates lens-capsulotomy-induced retinal degeneration in a mouse model of diabetes.

Diabetologia. 2018 Nov;61(11):2433-2446. doi: 10.1007/s00125-018-4682-3. Epub 2018 Jul 17.

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Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4281-7. doi: 10.1167/iovs.04-1361.

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Invest Ophthalmol Vis Sci. 2017 Dec 1;58(14):6365-6373. doi: 10.1167/iovs.17-22736.

引用本文的文献

Novel peptidomimetic compounds attenuate hypoxic-ischemic brain injury in neonatal rats.

Exp Neurol. 2025 Apr;386:115151. doi: 10.1016/j.expneurol.2025.115151. Epub 2025 Jan 19.

Peptidomimetic inhibitors targeting TrkB/PSD-95 signaling improves cognition and seizure outcomes in an Angelman Syndrome mouse model.

Neuropsychopharmacology. 2025 Apr;50(5):772-782. doi: 10.1038/s41386-024-02020-z. Epub 2024 Nov 7.

Cell and molecular targeted therapies for diabetic retinopathy.

Front Endocrinol (Lausanne). 2024 Jun 14;15:1416668. doi: 10.3389/fendo.2024.1416668. eCollection 2024.

本文引用的文献

Structure-based design of peptidomimetic inhibitors of PSD-95 with improved affinity for the PDZ3 domain.

FEBS Lett. 2024 Jan;598(2):233-241. doi: 10.1002/1873-3468.14767. Epub 2023 Nov 3.

A PSD-95 peptidomimetic mitigates neurological deficits in a mouse model of Angelman syndrome.

Prog Neurobiol. 2023 Nov;230:102513. doi: 10.1016/j.pneurobio.2023.102513. Epub 2023 Aug 1.

Neuroprotective Factors of the Retina and Their Role in Promoting Survival of Retinal Ganglion Cells: A Review.

Ophthalmic Res. 2021;64(3):345-355. doi: 10.1159/000514441. Epub 2021 Jan 15.

RELATIONSHIP BETWEEN STAGES OF DIABETIC RETINOPATHY AND LEVELS OF BRAIN-DERIVED NEUROTROPHIC FACTOR IN AQUEOUS HUMOR AND SERUM.

Retina. 2020 Jan;40(1):121-125. doi: 10.1097/IAE.0000000000002355.

Incidence and progression of diabetic retinopathy: a systematic review.

Lancet Diabetes Endocrinol. 2019 Feb;7(2):140-149. doi: 10.1016/S2213-8587(18)30128-1. Epub 2018 Jul 11.

Antidepression action of BDNF requires and is mimicked by Gαi1/3 expression in the hippocampus.

Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):E3549-E3558. doi: 10.1073/pnas.1722493115. Epub 2018 Mar 5.

Neuroprotection, Growth Factors and BDNF-TrkB Signalling in Retinal Degeneration.

Int J Mol Sci. 2016 Sep 20;17(9):1584. doi: 10.3390/ijms17091584.

Impairment of TrkB-PSD-95 signaling in Angelman syndrome.

PLoS Biol. 2013;11(2):e1001478. doi: 10.1371/journal.pbio.1001478. Epub 2013 Feb 12.

Deletion of the BDNF truncated receptor TrkB.T1 delays disease onset in a mouse model of amyotrophic lateral sclerosis.

PLoS One. 2012;7(6):e39946. doi: 10.1371/journal.pone.0039946. Epub 2012 Jun 27.

Retinal ganglion cells in diabetes.

J Physiol. 2008 Sep 15;586(18):4401-8. doi: 10.1113/jphysiol.2008.156695. Epub 2008 Jun 19.

Syn3, a newly developed cyclic peptide and BDNF signaling enhancer, ameliorates retinal ganglion cell degeneration in diabetic retinopathy.

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Syn3, a newly developed cyclic peptide and BDNF signaling enhancer, ameliorates retinal ganglion cell degeneration in diabetic retinopathy.

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