Christiaansen J E, Sears D W
Proc Natl Acad Sci U S A. 1985 Jul;82(13):4482-5. doi: 10.1073/pnas.82.13.4482.
Significant cytotoxic lymphocyte-induced DNA fragmentation does not occur in four human target cells lysed by human natural killer lymphocytes, killer lymphocytes, or cytotoxic T lymphocytes. These results contrast with the extensive DNA fragmentation that occurs in murine target cells lysed by the analogous effector lymphocytes. Thus, DNA fragmentation, or the lack thereof, represents a species-specific difference between human and murine cells responding to lysis by cytotoxic lymphocytes. The DNase activity observed in murine cells is probably internally activated rather than delivered by the cytotoxic effector cells, since human killer lymphocytes selectively caused DNA fragmentation in murine but not in human target cells lysed by antibody-dependent cellular cytotoxicity.
在被人类自然杀伤淋巴细胞、杀伤淋巴细胞或细胞毒性T淋巴细胞裂解的四种人类靶细胞中，未发生显著的细胞毒性淋巴细胞诱导的DNA片段化。这些结果与被类似效应淋巴细胞裂解的小鼠靶细胞中发生的广泛DNA片段化形成对比。因此，DNA片段化或其缺失代表了人类和小鼠细胞在对细胞毒性淋巴细胞裂解反应方面的种属特异性差异。在小鼠细胞中观察到的DNA酶活性可能是内部激活的，而不是由细胞毒性效应细胞传递的，因为人类杀伤淋巴细胞在通过抗体依赖性细胞毒性裂解的小鼠靶细胞中选择性地导致了DNA片段化，而在人类靶细胞中则没有。
