Department of Gastrointestinal Endoscopy Center, Beijing Jingmei Group General Hospital, Beijing, China.
The Second Department of Internal Medicine, Huaping Hospital of Traditional Chinese Medicine, Lijiang City, Yunnan Province, China.
BMC Gastroenterol. 2024 May 14;24(1):162. doi: 10.1186/s12876-024-03251-6.
To systematically analyze risk factors for delayed postpolypectomy bleeding (DPPB) in colorectum.
We searched seven large databases from inception to July 2022 to identify studies that investigated risk factors for DPPB. The effect sizes were expressed by relative risk (RR) and 95% confidence interval (95% CI). The heterogeneity was analyzed by calculating I values and performing sensitivity analyses.
A total of 15 articles involving 24,074 subjects were included in the study. The incidence of DPPB was found to be 0.02% (95% CI, 0.01-0.03), with an I value of 98%. Our analysis revealed that male sex (RR = 1.64), history of hypertension (RR = 1.54), anticoagulation (RR = 4.04), polyp size (RR = 1.19), polyp size ≥ 10 mm (RR = 2.43), polyp size > 10 mm (RR = 3.83), polyps located in the right semicolon (RR = 2.48) and endoscopic mucosal resection (RR = 2.99) were risk factors for DPPB.
Male sex, hypertension, anticoagulation, polyp size, polyp size ≥ 10 mm, polyps located in the right semicolon, and endoscopic mucosal resection were the risk factors for DPPB. Based on our findings, we recommend that endoscopists should fully consider and implement effective intervention measures to minimize the risk of DPPB.
系统分析结直肠息肉切除术后迟发性出血（DPPB）的危险因素。
我们从建库到 2022 年 7 月检索了 7 个大型数据库，以确定研究 DPPB 危险因素的研究。效应大小表示为相对风险（RR）和 95%置信区间（95%CI）。通过计算 I 值和进行敏感性分析来分析异质性。
共有 15 篇涉及 24074 名受试者的文章纳入研究。DPPB 的发生率为 0.02%（95%CI，0.01-0.03），I 值为 98%。我们的分析表明，男性（RR=1.64）、高血压病史（RR=1.54）、抗凝治疗（RR=4.04）、息肉大小（RR=1.19）、息肉大小≥10mm（RR=2.43）、息肉大小>10mm（RR=3.83）、右半结肠息肉（RR=2.48）和内镜黏膜切除术（RR=2.99）是 DPPB 的危险因素。
男性、高血压、抗凝、息肉大小、息肉大小≥10mm、右半结肠息肉和内镜黏膜切除术是 DPPB 的危险因素。根据我们的研究结果，建议内镜医生应充分考虑并采取有效的干预措施，以最大限度地降低 DPPB 的风险。
