Infectious Diseases Department and Antimicrobial Resistance Research Center and Transmissible Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran.
Student Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
BMC Infect Dis. 2024 May 14;24(1):491. doi: 10.1186/s12879-024-09365-2.
Brucellosis, a zoonotic disease caused by Brucella species, poses a significant global health concern. Among its diverse clinical manifestations, neurobrucellosis remains an infrequent yet debilitating complication. Here, we present a rare case of neurobrucellosis with unusual presentations in a 45-year-old woman. The patient's clinical course included progressive lower extremity weakness, muscle wasting, and double vision, prompting a comprehensive diagnostic evaluation. Notable findings included polyneuropathy, elevated brucella agglutination titers in both cerebrospinal fluid and blood, abnormal EMG-NCV tests, and resolving symptoms with antibiotic therapy. The clinical presentation, diagnostic challenges, and differentiation from other neurological conditions are discussed. This case underscores the importance of considering neurobrucellosis in regions where brucellosis is prevalent and highlights this rare neurological complication's distinctive clinical and radiological features. Early recognition and appropriate treatment are crucial to mitigate the significant morbidity associated with neurobrucellosis.
布鲁氏菌病是由布鲁氏菌属引起的一种人畜共患疾病,对全球健康构成重大威胁。在其多种临床表现中,神经布鲁氏菌病仍然是一种罕见但使人虚弱的并发症。在这里,我们报告了一例 45 岁女性中不常见表现的神经布鲁氏菌病的罕见病例。该患者的临床病程包括进行性下肢无力、肌肉萎缩和复视,促使进行全面的诊断评估。值得注意的发现包括多发性神经病、脑脊液和血液中布鲁氏菌凝集滴度升高、异常的 EMG-NCV 检查以及抗生素治疗后症状缓解。讨论了临床表现、诊断挑战以及与其他神经系统疾病的鉴别。该病例强调了在布鲁氏菌病流行地区考虑神经布鲁氏菌病的重要性,并突出了这种罕见的神经并发症的独特临床和影像学特征。早期识别和适当治疗对于减轻与神经布鲁氏菌病相关的重大发病率至关重要。