Yudistira Goesti, Sudiro Melati, Afriani Dewi Yussy
Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine Padjadjaran University/ Dr. Hasan Sadikin General Hospital Bandung, Indonesia.
Iran J Otorhinolaryngol. 2024 May;36(3):467-473. doi: 10.22038/IJORL.2024.75070.3523.
Nasopharyngeal Carcinoma (NPC) is among the most common head and neck cancer, significantly affecting the growth of human tumors. Therefore, this study aimed to investigate platelet-to-lymphocyte ratio (PLR) as a measure of inflammation in patients with various stages of NPC.
This retrospective case-control study was conducted on patients diagnosed with NPC between 2016 and 2020 in Dr. Hasan Sadikin Bandung Hospital, Indonesia. Based on NPC classification criteria, patients were classified into early and advanced groups. Subsequently, the PLR ratio was calculated as the number of platelet divided by the absolute number of lymphocytes in the two groups, and the results were statistically analyzed using Unpaired T-test, Pearson, and Chi-square test.
A total of 102 patients with an age range of 40 to 49 years were included in this study. A slight correlation of 0.272 (P<0.001) was observed between PLR and clinical stage, while NPC patients with PLR value > 188 had a 2.7 times higher risk of advanced stage (RR=2.702).
The PLR was significantly related to the clinical stage of NPC cancer.
鼻咽癌（NPC）是最常见的头颈癌之一，对人类肿瘤的生长有显著影响。因此，本研究旨在探讨血小板与淋巴细胞比值（PLR）作为衡量不同阶段鼻咽癌患者炎症的指标。
本回顾性病例对照研究针对2016年至2020年期间在印度尼西亚万隆哈桑·萨迪金博士医院被诊断为鼻咽癌的患者进行。根据鼻咽癌分类标准，将患者分为早期和晚期组。随后，计算两组中血小板数量除以淋巴细胞绝对数量的PLR比值，并使用非配对t检验、Pearson检验和卡方检验对结果进行统计学分析。
本研究共纳入102例年龄在40至49岁之间的患者。观察到PLR与临床分期之间存在轻微相关性，相关系数为0.272（P<0.001），而PLR值>188的鼻咽癌患者晚期风险高2.7倍（RR=2.702）。
PLR与鼻咽癌的临床分期显著相关。
