治疗前淋巴细胞与单核细胞比值及血小板与淋巴细胞比值对鼻咽癌患者生存的预测价值

Predictive Value of Pretreatment Lymphocyte-to-Monocyte Ratio and Platelet-to-Lymphocyte Ratio in the Survival of Nasopharyngeal Carcinoma Patients.

作者信息

Chen Yibiao, Sun Jianda, Hu Dan, Zhang Jian, Xu Yuyun, Feng Huiting, Chen Zhijie, Luo Yi, Lou Yunlong, Wu Heming

机构信息

Department of Radiation Oncology, Meizhou People's Hospital (Huangtang Hospital), Meizhou Academy of Medical Sciences, Meizhou, People's Republic of China.

Guangdong Provincial Key Laboratory of Precision Medicine and Clinical Translational Research of Hakka Population, Meizhou People's Hospital (Huangtang Hospital), Meizhou Academy of Medical Sciences, Meizhou, People's Republic of China.

出版信息

Cancer Manag Res. 2021 Nov 23;13:8767-8779. doi: 10.2147/CMAR.S338394. eCollection 2021.

OBJECTIVE

The present study aimed to investigate the predictive value of some indexes, such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), systemic inflammatory response index (SIRI), and systemic immune-inflammatory index (SII) in the survival of nasopharyngeal carcinoma (NPC) and provide reference for the treatment.

METHODS

A retrospective analysis was performed on 216 patients from 2016 to 2018. The cutoff values of these indexes were determined by the receiver operating characteristic (ROC) curve. The prognostic value of the indexes was evaluated according to the rate of overall survival (OS), regional recurrence-free survival (RRFS), locoregional recurrence-free survival (LRRFS), and distant metastasis-free survival (DMFS).

RESULTS

The survival analysis showed that NLR ≤2.695 (P = 0.017) and PLR ≤140.065 (P = 0.041) were associated with poor OS; however, the LMR and SIRI showed no significant statistical significance. NLR ≤2.045 (P = 0.018) and PLR ≤125.605 (P = 0.003) were associated with poor RRFS, LMR ≤2.535 (P = 0.027) and PLR ≤140.065 (P = 0.009) were associated with poor DMFS, NLR ≤2.125 (P = 0.018) and PLR ≤132.645 (P = 0.026) were associated with poor LRRFS, respectively. Logistic regression analysis showed that low LMR (≤2.535) was significantly inferior in OS (HR 23.085, 95% CI 3.425-155.622, P = 0.001) and DMFS (HR 22.839, 95% CI 4.096-127.343, P < 0.001). Moreover, low PLR (≤140.065) remained significantly related to worse OS (HR 11.908, 95% CI 1.295-109.517, P = 0.029) and DMFS (HR 9.556, 95% CI 1.448-63.088, P = 0.019).

CONCLUSION

The index LMR and PLR can be used for predicting survival in NPC patients.

目的

本研究旨在探讨中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）、淋巴细胞与单核细胞比值（LMR）、全身炎症反应指数（SIRI）和全身免疫炎症指数（SII）等指标对鼻咽癌（NPC）患者生存的预测价值，为治疗提供参考。

方法

对2016年至2018年的216例患者进行回顾性分析。通过受试者工作特征（ROC）曲线确定这些指标的临界值。根据总生存（OS）率、区域无复发生存（RRFS）率、局部区域无复发生存（LRRFS）率和远处转移无复发生存（DMFS）率评估这些指标的预后价值。

结果

生存分析显示，NLR≤2.695（P = 0.017）和PLR≤140.065（P = 0.041）与较差的OS相关；然而，LMR和SIRI无显著统计学意义。NLR≤2.045（P = 0.018）和PLR≤125.605（P = 0.003）与较差的RRFS相关，LMR≤2.535（P = 0.027）和PLR≤140.065（P = 0.009）与较差的DMFS相关，NLR≤2.125（P = 0.018）和PLR≤132.645（P = 0.026）分别与较差的LRRFS相关。Logistic回归分析显示，低LMR（≤2.535）在OS（HR 23.085，95%CI 3.425 - 155.622，P = 0.001）和DMFS（HR 22.839，95%CI 4.096 - 127.343，P < 0.001）方面显著较差。此外，低PLR（≤140.065）仍与较差的OS（HR 11.908，95%CI 1.295 - 109.517，P = 0.029）和DMFS（HR 9.556，95%CI 1.448 - 63.088，P = 0.019）显著相关。