Grigoryan Mark, Manukyan Violeta, Hovhannisyan Saten, Apresyan Hripsime
Infectious Diseases, Muratsan University Hospital Complex, Yerevan, ARM.
Infectious Diseases, Yerevan State Medical University, Yerevan, ARM.
Cureus. 2024 Apr 14;16(4):e58237. doi: 10.7759/cureus.58237. eCollection 2024 Apr.
Visceral leishmaniasis (VL) is a parasitic vector-borne disease endemic in Armenia. Its complications include hemophagocytic lymphohistiocytosis (HLH), which is a potentially fatal syndrome if misdiagnosed or left untreated. Higher clinical caution is required for the prompt diagnosis of HLH since the clinical findings associated with systemic inflammation overlap with those of many other pathological conditions, such as sepsis or Kawasaki disease. This study aims to provide an overview of the most common presentations that should prompt consideration of HLH. We described a case series of three pediatric patients with VL who developed HLH during antiparasitic treatment and received total doses of 40 mg/kg of liposomal amphotericin B for complete elimination of the pathogen.
内脏利什曼病（VL）是一种在亚美尼亚流行的寄生虫媒介传播疾病。其并发症包括噬血细胞性淋巴组织细胞增生症（HLH），如果误诊或不治疗，这是一种潜在的致命综合征。由于与全身炎症相关的临床发现与许多其他病理状况（如败血症或川崎病）的临床发现重叠，因此需要更高的临床警惕性来及时诊断HLH。本研究旨在概述那些应促使考虑HLH的最常见表现。我们描述了一个病例系列，三名患有VL的儿科患者在抗寄生虫治疗期间发生了HLH，并接受了40mg/kg的脂质体两性霉素B总剂量以完全清除病原体。
