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内脏利什曼病中的噬血细胞性淋巴组织细胞增生症：一种罕见但可治疗的并发症。

Hemophagocytic Lymphohistiocytosis in Visceral Leishmaniasis: A Rare yet Treatable Complication.

作者信息

Varshney Anupam, Solanki Ranjan, Manna David, Rodriguez Efren, Bindra Vijay K

机构信息

Department of Pathology, Muzaffarnagar Medical College and Hospital, Muzaffarnagar, IND.

Department of Basic Biomedical Sciences, Touro College of Osteopathic Medicine, Middletown, USA.

出版信息

Cureus. 2024 Sep 24;16(9):e70104. doi: 10.7759/cureus.70104. eCollection 2024 Sep.

DOI:10.7759/cureus.70104
PMID:39449916
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11501513/
Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a rare debilitating condition that can be triggered by an infectious cause, often linked to the Epstein-Barr virus (EBV). In this case, we evaluated a patient with pancytopenia. The bone marrow aspiration revealed the presence of amastigotes and active hemophagocytosis, indicating that the HLH was induced by a infection. The patient was treated with lyophilized amphotericin B followed by miltefosine, which effectively resolved the infection and HLH. This case report underscores the presentation and findings of -induced HLH, as well as the successful treatment approach that led to improved patient outcomes.

摘要

噬血细胞性淋巴组织细胞增生症（HLH）是一种罕见的使人衰弱的病症，可由感染因素引发，通常与爱泼斯坦-巴尔病毒（EBV）有关。在本病例中，我们评估了一名全血细胞减少症患者。骨髓穿刺显示存在无鞭毛体和活跃的噬血细胞现象，表明HLH是由感染引起的。该患者接受了冻干两性霉素B治疗，随后使用米替福新，有效解决了感染和HLH问题。本病例报告强调了感染诱发的HLH的表现和发现，以及导致患者预后改善的成功治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7c7/11501513/df9badb9f09b/cureus-0016-00000070104-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7c7/11501513/8466fdbbb165/cureus-0016-00000070104-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7c7/11501513/e26c5325a896/cureus-0016-00000070104-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7c7/11501513/df9badb9f09b/cureus-0016-00000070104-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7c7/11501513/8466fdbbb165/cureus-0016-00000070104-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7c7/11501513/e26c5325a896/cureus-0016-00000070104-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7c7/11501513/df9badb9f09b/cureus-0016-00000070104-i03.jpg

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本文引用的文献

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A Case Series of Hemophagocytic Lymphohistiocytosis: An Atypical Presentation of Visceral Leishmaniasis.噬血细胞性淋巴组织细胞增生症病例系列：内脏利什曼病的非典型表现
Cureus. 2024 Apr 14;16(4):e58237. doi: 10.7759/cureus.58237. eCollection 2024 Apr.
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Inpatient recognition and management of HLH.HLH 的住院患者识别与管理。
Hematology Am Soc Hematol Educ Program. 2023 Dec 8;2023(1):259-266. doi: 10.1182/hematology.2023000509.
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The 2022 EULAR/ACR points to consider at the early stages of diagnosis and management of suspected haemophagocytic lymphohistiocytosis/macrophage activation syndrome (HLH/MAS).
2022 年 EULAR/ACR 在疑似噬血细胞性淋巴组织细胞增生症/巨噬细胞活化综合征（HLH/MAS）的早期诊断和管理中需要考虑的要点。
Ann Rheum Dis. 2023 Oct;82(10):1271-1285. doi: 10.1136/ard-2023-224123. Epub 2023 Jul 24.
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Case Report: Diagnosis and Treatment of Two Clinical Cases of Visceral Leishmaniasis-Related Hemophagocytic Lymphohistiocytosis.病例报告：两例内脏利什曼病相关噬血细胞性淋巴组织细胞增生症的诊断与治疗。
Am J Trop Med Hyg. 2023 Jul 10;109(2):296-300. doi: 10.4269/ajtmh.22-0776. Print 2023 Aug 2.
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Platelet Counting: Ugly Traps and Good Advice. Proposals from the French-Speaking Cellular Hematology Group (GFHC).血小板计数：棘手的陷阱与实用建议。来自法语区细胞血液学小组（GFHC）的提议。
J Clin Med. 2020 Mar 16;9(3):808. doi: 10.3390/jcm9030808.
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Pediatric hemophagocytic lymphohistiocytosis.儿童噬血细胞性淋巴组织细胞增生症。
Blood. 2020 Apr 16;135(16):1332-1343. doi: 10.1182/blood.2019000936.
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Challenges in the diagnosis of hemophagocytic lymphohistiocytosis: Recommendations from the North American Consortium for Histiocytosis (NACHO).噬血细胞性淋巴组织细胞增生症诊断中的挑战：北美组织细胞增生症联盟（NACHO）的建议。
Pediatr Blood Cancer. 2019 Nov;66(11):e27929. doi: 10.1002/pbc.27929. Epub 2019 Jul 24.
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Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017.全球、地区和国家残疾调整生命年（DALYs）359 种疾病和伤害以及 195 个国家和地区 1990-2017 年的健康期望寿命（HALE）：2017 年全球疾病负担研究的系统分析。
Lancet. 2018 Nov 10;392(10159):1859-1922. doi: 10.1016/S0140-6736(18)32335-3.
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Leishmaniasis.利什曼病。
Lancet. 2018 Sep 15;392(10151):951-970. doi: 10.1016/S0140-6736(18)31204-2. Epub 2018 Aug 17.
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Hemophagocytic Lymphohistiocytosis.噬血细胞性淋巴组织细胞增生症。
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