Kasule Sabirah N, Grant Leah M, Apolinario Michael A, Speiser Lisa J, Saling Christopher F, Blair Janis E, Vikram Holenarasipur R
Infectious Diseases, Mayo Clinic, Phoenix, USA.
Cardiology, Mayo Clinic, Phoenix, USA.
Cureus. 2024 May 14;16(5):e60285. doi: 10.7759/cureus.60285. eCollection 2024 May.
We describe a recent case of bioprosthetic aortic valve infective endocarditis successfully managed at our institution. This led us to perform a literature review of endemic fungal infective endocarditis in the United States caused by , , and . Symptoms preceded infective endocarditis diagnosis by several months. Patients with and infective endocarditis were younger with fewer comorbid conditions. Valvular involvement was relatively uncommon in infective endocarditis (27%). Fungemia was noted in patients with infective endocarditis due to (30%) and (18%). Mortality rates for infective endocarditis were high (, 46%; , 58%; , 80%); infective endocarditis was commonly diagnosed post-mortem ( 58%; 89%). Most surviving patients with infective endocarditis ( 79%; 80%) underwent valve surgery along with prolonged antifungal therapy. The two surviving patients with infective endocarditis received antifungal therapy without surgery.
我们描述了我院近期成功治疗的一例生物人工主动脉瓣感染性心内膜炎病例。这促使我们对美国由[具体真菌名称1]、[具体真菌名称2]和[具体真菌名称3]引起的地方性真菌性感染性心内膜炎进行文献综述。症状在感染性心内膜炎诊断前出现数月。患有[真菌名称1]和[真菌名称2]感染性心内膜炎的患者较年轻，合并症较少。瓣膜受累在[真菌名称3]感染性心内膜炎中相对少见（27%）。在由[真菌名称1]（30%）和[真菌名称2]（18%）引起的感染性心内膜炎患者中发现了真菌血症。感染性心内膜炎的死亡率很高（[真菌名称1]为46%；[真菌名称2]为58%；[真菌名称3]为80%）；感染性心内膜炎通常在尸检时被诊断（[真菌名称1]为58%；[真菌名称2]为89%）。大多数存活的感染性心内膜炎患者（[真菌名称1]为79%；[真菌名称2]为80%）接受了瓣膜手术以及延长的抗真菌治疗。两名存活的[真菌名称3]感染性心内膜炎患者接受了抗真菌治疗但未进行手术。
