分枝杆菌与索状因子对补体替代途径的激活作用。
Activation of the alternative pathway of complement by mycobacteria and cord factor.
作者信息
Ramanathan V D, Curtis J, Turk J L
出版信息
Infect Immun. 1980 Jul;29(1):30-5. doi: 10.1128/iai.29.1.30-35.1980.
Abstract
The ability of a number of mycobacteria and some of their components to activate complement was examined. Mycobacterium bovis BCG (Glaxo strain), Mycobacterium leprae, Mycobacterium lepraemurium, and cord factor activated the alternative pathway of complement in normal human serum and normal and C4-deficient guinea pig sera and generated biologically active products. BCG (Pasteur strain) and muramyl dipeptide did not activate complement. The relevance of activation of complement by mycobacteria to their induction of granulomas is discussed.
摘要
研究了多种分枝杆菌及其某些成分激活补体的能力。牛型结核分枝杆菌卡介苗（葛兰素株）、麻风分枝杆菌、鼠麻风分枝杆菌和索状因子可激活正常人血清以及正常和C4缺陷豚鼠血清中的补体替代途径，并产生生物活性产物。卡介苗（巴斯德株）和胞壁酰二肽不能激活补体。讨论了分枝杆菌激活补体与其诱导肉芽肿之间的相关性。
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