Berezhnaia N M, Iakhimovich L V, Dorfman M V
Eksp Onkol. 1985;7(3):37-40.
Peculiarities of interaction of tumour cells and lymphocytes were studied in cultivating explants of 19 human lung tumours in diffusion chambers. Results were analyzed with due regard for the histological structure of tumours, level of tissue differentiation and clinical stage of the disease. Criteria are developed for evaluating the interaction of tumour cells and lymphocytes, namely: the relative content of lymphocytes in culture, the number of spheroids and a way of their destruction (edge one or with lymphocytes), presence of lymphocytic clusters and aggregates of blast-like cells, presence of tumour cell-lymphocyte complexes. The obtained results may be used for estimation of the tumour malignancy degree.
在扩散小室中培养19例人肺肿瘤外植体，研究肿瘤细胞与淋巴细胞相互作用的特点。分析结果时适当考虑了肿瘤的组织结构、组织分化程度和疾病的临床分期。制定了评估肿瘤细胞与淋巴细胞相互作用的标准，即：培养物中淋巴细胞的相对含量、球体数量及其破坏方式（边缘破坏或与淋巴细胞一起破坏）、淋巴细胞簇和母细胞样细胞聚集体的存在、肿瘤细胞 - 淋巴细胞复合物的存在。所得结果可用于评估肿瘤的恶性程度。
