School of Marine Science and Technology, Harbin Institute of Technology, Weihai, Shandong 264209, People's Republic of China.
Marine College, Shandong University, Weihai, Shandong 264209, People's Republic of China.
J Chem Phys. 2024 May 7;160(17). doi: 10.1063/5.0207594.
Fatty acids from cooking fumes and hypochlorous acid (HOCl) released from indoor cleaning adversely affect respiratory health, but the molecular-level mechanism remains unclear. Here, the effect of cooking oil fumes [palmitic acid (PA), oleic acid (OA), and linoleic acid (LA)] on lung model phospholipid (POPG) hydrochlorination mediated by HOCl at the air-water interface of the hanged droplets was investigated. Interfacial hydrochlorination of POPG was impeded by OA and LA, while that of POPG was facilitated by PA. The effect on POPG hydrochlorination increased with the decrease in oil fume concentration. A potential mechanism with respect to the chain length of these oil fumes, regardless of their saturation, was proposed. PA with a short carbon chain looses the POPG packing and leads to the exposure of the C=C double bonds of POPG, whereas OA and LA with a long carbon chain hinder HOCl from reaching the C=C bonds of POPG. These results for short chain and low concentration dependence suggest that the decay of oil fumes or the conversion of short-chain species by indoor interfacial chemistry might be adverse to lung health. These results provide insights into the relationship between indoor multicomponent pollutants and the respiratory system.
烹饪油烟和室内清洁释放的次氯酸（HOCl）中的脂肪酸会对呼吸道健康造成不良影响，但分子水平的机制尚不清楚。在这里，研究了在悬挂液滴的气液界面上，HOCl 介导的烹饪油烟（棕榈酸（PA）、油酸（OA）和亚油酸（LA））对肺模型磷脂（POPG）氯化的影响。OA 和 LA 阻碍了 POPG 的界面氯化，而 PA 则促进了 POPG 的界面氯化。POPG 氯化的这种影响随着油烟浓度的降低而增加。提出了一个与这些油烟的链长有关的潜在机制，而与它们的饱和度无关。短链的 PA 会破坏 POPG 的堆积，导致 POPG 的 C=C 双键暴露，而长链的 OA 和 LA 则阻碍 HOCl 到达 POPG 的 C=C 键。这种对短链和低浓度的依赖性的结果表明，室内界面化学中油烟的衰减或短链物质的转化可能对肺部健康不利。这些结果为室内多组分污染物与呼吸系统之间的关系提供了深入的了解。
