Department of Chemistry and Biochemistry, M. S. Ramaiah College of Arts, Science and Commerce, Bengaluru, India.
Department of Sanskrit, M. S. Ramaiah College of Arts, Science and Commerce, Bengaluru, India.
J Immunoassay Immunochem. 2024 May 3;45(3):153-177. doi: 10.1080/15321819.2024.2353766. Epub 2024 May 15.
Dr. Henrik Sjögren after whom Sjögren's Syndrome is named, was a Swedish ophthalmologist who identified the syndrome which had three main symptoms namely, dry eyes, dry mouth, and arthritis. His contributions also highlighted the systemic complications of the syndrome which made our understanding of this disease better. Since then, there have been several studies on Sjögren's Syndrome (SS) of which two of them have changed the perception of the disease's prevalence. The first was a British study in the late 1990s which indicated this syndrome was no more a rare condition. The second is a 2008 study in the US which placed the syndrome as the second most prevalent autoimmune disease after rheumatoid arthritis (RA). Being one of the most prevalent autoimmune disease, there is a pressing need for a more profound and comprehensive understanding of the syndrome. This review endeavors to offer a comprehensive overview of the disease, encompassing its prevalence, manifestations, mechanisms, genetic factors, diagnostic methods, and treatment options. This review additionally offers the viewpoint on SS and its symptoms. This supplementary insight has the potential to contribute to the development of an integrated and holistic approach to managing the condition.
被命名为干燥综合征的舍格伦博士（Henrik Sjögren）是一位瑞典眼科医生，他发现了这种综合征，其主要有三个症状，即眼睛干燥、口干和关节炎。他的贡献还强调了该综合征的系统性并发症，使我们对这种疾病有了更好的理解。从那时起，已经有几项关于干燥综合征（SS）的研究，其中两项研究改变了对该疾病患病率的看法。第一项是 20 世纪 90 年代末英国的一项研究，表明这种综合征不再是一种罕见的疾病。第二项是 2008 年美国的一项研究，将该综合征列为仅次于类风湿关节炎（RA）的第二大常见自身免疫性疾病。作为最常见的自身免疫性疾病之一，迫切需要更深入和全面地了解这种疾病。这篇综述旨在提供对该疾病的全面概述，包括其患病率、表现、机制、遗传因素、诊断方法和治疗选择。此外，这篇综述还提供了对 SS 及其症状的观点。这种补充的见解有可能为管理这种疾病提供一种综合和整体的方法。
