胰腺炎四季谈——全年中急性胰腺炎的发病时节。
The four seasons of pancreatitis - Etiology of acute pancreatitis during the course of the year.
机构信息
Department of Medicine II, LMU University Hospital, Munich, Germany.
Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Centre Goettingen, Goettingen, Germany.
出版信息
Z Gastroenterol. 2024 Aug;62(8):1207-1210. doi: 10.1055/a-2293-7813. Epub 2024 May 15.
BACKGROUND/OBJECTIVES: Whether seasonality is a factor that influences the incidence of acute pancreatitis (AP) is an under-investigated area. If seasonal incidence peaks can be detected, specifically with regard to biliary pancreatitis, has so far been answered in contradictory ways in the literature.
METHODS
All AP cases from two tertiary German referral centers were identified between 2016 and 2022 based on ICD-10 discharge codes. The test for goodness of fit was applied to test significant differences in monthly and seasonal distributions of AP admissions.
RESULTS
In total, 3597 AP cases were included. We observed significantly more idiopathic and biliary cases in May to July (p-values 0.041 and 0.027, respectively). Furthermore, most drug-induced APs were identified during the winter months (p-value 0.006). Moreover, there was a significant peak of alcohol-induced pancreatitis in summer and fall (p-value 0.038).
CONCLUSIONS
Our data indicate a seasonal impact on AP incidences for certain etiologies.
背景/目的：季节是否是影响急性胰腺炎（AP）发病率的一个因素，这是一个研究不足的领域。如果可以检测到季节性发病高峰，特别是在胆源性胰腺炎方面，目前在文献中已经以相互矛盾的方式回答了这个问题。
方法
根据 ICD-10 出院代码，我们确定了 2016 年至 2022 年期间来自两个德国三级转诊中心的所有 AP 病例。拟合优度检验用于检验 AP 入院的月度和季节性分布是否存在显著差异。
结果
共纳入 3597 例 AP 病例。我们观察到 5 月至 7 月间特发性和胆源性 AP 病例明显增多（p 值分别为 0.041 和 0.027）。此外，大多数药物性 AP 发生在冬季（p 值为 0.006）。此外，酒精性胰腺炎在夏季和秋季有明显的发病高峰（p 值为 0.038）。
结论
我们的数据表明，某些病因的 AP 发病率存在季节性影响。
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